Malondialdehyde, nitric oxide and adrenomedullin levels in patients with primary dysmenorrhea

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dc.authoridYurekli, Muhittin/0000-0002-5830-8564
dc.authoridBalat, Ayse/0000-0002-8904-1348;
dc.authorwosidYurekli, Muhittin/B-4414-2016
dc.authorwosidBalat, Ayse/JOZ-8426-2023
dc.authorwosidcekmen, mustafa baki/G-6122-2011
dc.contributor.authorDikensoy, Ebru
dc.contributor.authorBalat, Ozcan
dc.contributor.authorPence, Sadrettin
dc.contributor.authorBalat, Ayse
dc.contributor.authorCekmen, Mustafa
dc.contributor.authorYurekli, Muhuttin
dc.date.accessioned2024-08-04T20:31:02Z
dc.date.available2024-08-04T20:31:02Z
dc.date.issued2008
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAim: The aim of the study was to examine whether there was a relationship between primary dysmenorrhea and serum levels of malondialdehyde (MDA), nitric oxide (NO) and adrenomedullin (AM) in young women. Methods: Sixty female subjects without serious medical problems, aged between 20 and 34, who had regular menses for at least six previous cycles, were involved. Blood samples were obtained from each patient on the first and the 21st days of her menstrual cycles. Pelvic examination and ultrasound were performed to determine any organic cause for dysmenorrhea in each patient. The subjects were divided into two groups. The study group consisted of 30 subjects with primary dysmenorrhea, and the control group consisted of 30 healthy subjects. Results: No statistically significant difference was observed in comparison of the following variables between the groups: age, parity and body mass index. The serum levels of MDA, NO, and AM were significantly higher on the first day compared to those on the 21(st) day in the study group (P < 0.05). The serum levels of MDA, NO, and AM were significantly higher in the study group compared to the control group both on the first and the 21st days of the menstrual cycles (P < 0.05). Conclusion: In conclusion, the results of this study showed that the serum levels of MDA, NO, and AM increase in subjects with primary dysmenorrhea, suggesting the possibility that lipid peroxidation and oxidative stress play a significant role in the etiopathogenesis of primary dysmenorrhea.en_US
dc.identifier.doi10.1111/j.1447-0756.2008.00802.x
dc.identifier.endpage1053en_US
dc.identifier.issn1341-8076
dc.identifier.issn1447-0756
dc.identifier.issue6en_US
dc.identifier.pmid19012707en_US
dc.identifier.scopus2-s2.0-55649096831en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1049en_US
dc.identifier.urihttps://doi.org/10.1111/j.1447-0756.2008.00802.x
dc.identifier.urihttps://hdl.handle.net/11616/94687
dc.identifier.volume34en_US
dc.identifier.wosWOS:000260544600021en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Obstetrics and Gynaecology Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectadrenomedullinen_US
dc.subjectmalondialdehydeen_US
dc.subjectnitric oxideen_US
dc.subjectprimary dysmenorrhealen_US
dc.titleMalondialdehyde, nitric oxide and adrenomedullin levels in patients with primary dysmenorrheaen_US
dc.typeArticleen_US

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