Synthesis, structural characterization and cytotoxicity studies of T-shaped silver(I) complexes derived from 1-benzyl-3H-benzimidazolium p-toluenesulfonates

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dc.authoridBALCIOGLU, Sevgi/0000-0003-0724-4772
dc.authoridÖzdemir, Namık/0000-0003-3371-9874
dc.authoridALICI, Bulent/0000-0001-5009-3223
dc.authoridKarataş, Mert Olgun/0000-0001-8500-2088
dc.authoridAteş, Burhan/0000-0001-6080-229X
dc.authoridBALCIOGLU, Sevgi/0000-0003-0724-4772
dc.authorwosidBALCIOGLU, Sevgi/O-3576-2015
dc.authorwosidÖzdemir, Namık/J-6434-2015
dc.authorwosidALICI, Bulent/AAG-4203-2019
dc.authorwosidKarataş, Mert Olgun/ABG-7848-2020
dc.authorwosidAteş, Burhan/AAA-3730-2021
dc.authorwosidBALCIOGLU, Sevgi/W-5874-2018
dc.contributor.authorKarlik, Ozgul
dc.contributor.authorBalcioglu, Sevgi
dc.contributor.authorKaratas, Mert Olgun
dc.contributor.authorAtes, Burhan
dc.contributor.authorAlici, Bulent
dc.contributor.authorOzdemir, Namik
dc.date.accessioned2024-08-04T20:44:15Z
dc.date.available2024-08-04T20:44:15Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn the present study, we synthesized novel benzimidazole-silver(I) complexes (2a-d) by the interaction of 1-benzyl-3H-benzimidazolium p-toluenesulfonate derivatives (1a-d) and Ag2O in order to investigate their anticancer properties. All the salts and complexes were fully characterized by H-1 NMR, C-13 NMR, IR and LC-MS spectroscopic techniques, elemental analysis and single crystal X-ray crystallography. Cytotoxic effects of compounds were investigated by MTT test against human colorectal (Caco-2), breast (MCF-7) cancer cell lines and non cancer mouse fibroblast (L-929) cell lines. All the complexes performed more cytotoxicity than cisplatin against Caco-2 cell lines while they were not active against MCF-7 in the treatment concentrations. Among the complexes, 2d which contains chlorine at 2-position of benzyl was found out as most active but not selective for non cancer L-929 cell lines. The complex 2b which contains methyl instead of chlorine at 2d showed approximately equal cytotoxicity as cisplatin against L-929 cell lines while this complex was twofold active than cisplatin against Caco-2 cell lines. These findings suggest that complex 2b is a promising candidate for treatment of colorectal cancer. (C) 2018 Elsevier Ltd. All rights reserved.en_US
dc.description.sponsorshipInonu University Research Fund (IUBAP) [2016-101]en_US
dc.description.sponsorshipThis work was financially supported by Inonu University Research Fund (IUBAP Project no: 2016-101).en_US
dc.identifier.doi10.1016/j.poly.2017.12.033
dc.identifier.endpage70en_US
dc.identifier.issn0277-5387
dc.identifier.scopus2-s2.0-85040328119en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage63en_US
dc.identifier.urihttps://doi.org/10.1016/j.poly.2017.12.033
dc.identifier.urihttps://hdl.handle.net/11616/98111
dc.identifier.volume142en_US
dc.identifier.wosWOS:000425571300009en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofPolyhedronen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSilveren_US
dc.subjectBenzimidazoleen_US
dc.subjectCytotoxicityen_US
dc.subjectBreast canceren_US
dc.subjectColorectal canceren_US
dc.titleSynthesis, structural characterization and cytotoxicity studies of T-shaped silver(I) complexes derived from 1-benzyl-3H-benzimidazolium p-toluenesulfonatesen_US
dc.typeArticleen_US

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