Effects of pregnancy and lactation on bone mineral density, and their relation to the serum calcium, phosphorus, calcitonin and parathyroid hormone levels in rats

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dc.authoridSahin, Ibrahim/0000-0002-6231-0034
dc.authoridYologlu, Saim/0000-0002-9619-3462
dc.authoridKOVALAK, EMRAH/0000-0003-0121-9082
dc.authorwosidGONEN, EMEL/AAJ-2510-2021
dc.authorwosidSahin, Ibrahim/ABI-6050-2020
dc.authorwosidYologlu, Saim/ABI-8014-2020
dc.authorwosidŞahin, İbrahim/HHY-8303-2022
dc.contributor.authorGonen, E
dc.contributor.authorSahin, I
dc.contributor.authorOzbek, M
dc.contributor.authorKovalak, E
dc.contributor.authorYologlu, S
dc.contributor.authorAtes, Y
dc.date.accessioned2024-08-04T20:14:55Z
dc.date.available2024-08-04T20:14:55Z
dc.date.issued2005
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe aim of this study was to evaluate the net changes in bone mineral density (BMD) during the reproductive cycle, and their relation with changes in serum calcium (Ca), phosphorus (P), PTH and calcitonin levels in rats. Twenty-seven female Wistar rats were included in this study. They were divided into three groups as pregnant, lactating and control groups. BMDs of lumbar vertebrates, femoral and tibial bones, and Ca, P, calcitonin and PTH levels were measured at the end of pregnancy, at the end of lactation and in nulliparous controls. In the pregnant group, the BMDs of rats were significantly higher in lumbar vertebrates, femoral and tibia bones than those of the control group (p < 0.05). Their PTH and Ca levels were significantly lower than the control group (p < 0.05). However, no statistically significant difference was found regarding P and calcitonin levels when compared to those of the control group. In the lactating group, the BMDs were significantly lower in lumbar vertebrates, femoral and tibia bones than those seen in the control and pregnant groups (p < 0.05). Ca and PTH levels were significantly higher in lactating rats than in those of pregnant rats (p < 0.005). Normal pregnancy increases BMD in rats, whereas lactation decreases it. Change in PTH levels is supposed to contribute to the mineralization and demineralization of the skeleton during pregnancy and lactation, respectively. (c) 2005, Editrice Kurtis.en_US
dc.identifier.doi10.1007/BF03347197
dc.identifier.endpage326en_US
dc.identifier.issn1720-8386
dc.identifier.issue4en_US
dc.identifier.pmid15966504en_US
dc.identifier.scopus2-s2.0-23444435108en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage322en_US
dc.identifier.urihttps://doi.org/10.1007/BF03347197
dc.identifier.urihttps://hdl.handle.net/11616/94053
dc.identifier.volume28en_US
dc.identifier.wosWOS:000229444100004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal of Endocrinological Investigationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectpregnancyen_US
dc.subjectlactationen_US
dc.subjectbone mineral densityen_US
dc.subjectCaen_US
dc.subjectPTHen_US
dc.titleEffects of pregnancy and lactation on bone mineral density, and their relation to the serum calcium, phosphorus, calcitonin and parathyroid hormone levels in ratsen_US
dc.typeArticleen_US

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