Syntheses of 1,2,3-triazole-bridged pyranose sugars with purine and pyrimidine nucleobases and evaluation of their anticancer potential

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dc.authoridSalva, Emine/0000-0002-1159-5850
dc.authoridŞALVA, EMINE/0000-0002-1159-5850
dc.authoridHalay, Erkan/0000-0002-0084-7709
dc.authorwosidSalva, Emine/ABI-2766-2020
dc.authorwosidAY, EMRİYE/AAW-9002-2020
dc.authorwosidŞALVA, EMINE/CAH-3062-2022
dc.authorwosidKARAYILDIRIM, Tamer/G-1090-2018
dc.authorwosidHalay, Erkan/C-3191-2018
dc.contributor.authorHalay, Erkan
dc.contributor.authorAy, Emriye
dc.contributor.authorSalva, Emine
dc.contributor.authorAy, Kadir
dc.contributor.authorKarayildirim, Tamer
dc.date.accessioned2024-08-04T20:44:06Z
dc.date.available2024-08-04T20:44:06Z
dc.date.issued2017
dc.departmentİnönü Üniversitesien_US
dc.description.abstractWith the aim to create a library of compounds with potential bioactivities by combining special characteristics of two important groups such as nucleobases and carbohydrates, twenty 1,4-disubstituted-triazole nucleosides were synthesized in good yields (80-94%) using the copper catalyzed Click' reaction between azido-modified pento- or hexopyranoses and alkyne-bearing pyrimidine or purine nucleobases. Structural elucidation was made with the assistance of spectroscopic techniques such as FTIR, 1D-, 2D-NMR, and ESI-TOFMS. All the synthesized triazole nucleosides were evaluated for their cytotoxic activity against three human cancer cell lines (MDA-MB-231, Hep3B, PC-3) by using the MTT assay. Particularly, compounds 3a and 1b were identified as potential hits against Hep3B cell.en_US
dc.description.sponsorshipTUBITAK-Research Council of Turkey [114Z757]; TUBITAK-BIDEB [2211A]en_US
dc.description.sponsorshipThis work was supported by TUBITAK-Research Council of Turkey with the project number 114Z757. Halay also offers his profound thanks to TUBITAK-BIDEB 2211A for scholarship support.en_US
dc.identifier.doi10.1080/15257770.2017.1346258
dc.identifier.endpage619en_US
dc.identifier.issn1525-7770
dc.identifier.issn1532-2335
dc.identifier.issue9en_US
dc.identifier.pmid29087802en_US
dc.identifier.scopus2-s2.0-85032738195en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage598en_US
dc.identifier.urihttps://doi.org/10.1080/15257770.2017.1346258
dc.identifier.urihttps://hdl.handle.net/11616/98015
dc.identifier.volume36en_US
dc.identifier.wosWOS:000415710500004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofNucleosides Nucleotides & Nucleic Acidsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectClick chemistryen_US
dc.subject1,2,3-Triazolesen_US
dc.subjectazido sugarsen_US
dc.subjectnucleobasesen_US
dc.subjectnucleosidesen_US
dc.subjectanticancer activityen_US
dc.titleSyntheses of 1,2,3-triazole-bridged pyranose sugars with purine and pyrimidine nucleobases and evaluation of their anticancer potentialen_US
dc.typeArticleen_US

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