Melatonin reduces torsion-detorsion injury in rat ovary: biochemical and histopathologic evaluation

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dc.authoridTürköz, Yusuf/0000-0001-5401-0720
dc.authoridYologlu, Saim/0000-0002-9619-3462
dc.authoridCigremis, Yilmaz/0000-0002-8600-0946
dc.authorwosidCigremis, Yilmaz/JAC-8451-2023
dc.authorwosidTürköz, Yusuf/ABG-7931-2020
dc.authorwosidYologlu, Saim/ABI-8014-2020
dc.authorwosidCigremis, Yilmaz/O-6019-2015
dc.contributor.authorTurkoz, Y
dc.contributor.authorCelik, O
dc.contributor.authorHascalik, S
dc.contributor.authorCigremis, Y
dc.contributor.authorHascalik, M
dc.contributor.authorMizrak, B
dc.contributor.authorYologlu, S
dc.date.accessioned2024-08-04T20:30:48Z
dc.date.available2024-08-04T20:30:48Z
dc.date.issued2004
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThis experimental study was designed to determine the effects of melatonin on the levels of malondialdehyde (MDA), reduced glutathione (GSH), xanthine oxidase (XO) after adnexial torsion/detorsion (ischemia/reperfusion, I/R) of the ovaries of in rats. Forty adult albino rats were divided into five groups: sham operation, torsion, I/R plus saline, I/R plus melatonin and torsion plus melatonin. Rats in the sham-operated group underwent a surgical procedure similar to the other groups but the adnexa was not occluded. Rats in the torsion group were killed after adnexal torsion for 3 hr. Melatonin and saline were injected intraperitoneally (10 mg/kg) 30 min before detorsion to the I/R plus melatonin group and I/R plus saline group respectively. After 3 hr of ovarian detorsion, the rats were killed and ovaries were removed. Melatonin was injected intraperitoneally (10 mg/kg) 30 min before torsion to the torsion plus melatonin group. After 3 hr of ovarian torsion, the rats were killed and ovaries were harvested. The tissue levels of MDA, GSH and XO were measured. MDA and XO levels in the I/R plus saline group increased significantly when compared with torsion and sham-operated groups (P < 0.001). MDA and XO levels in the I/R plus melatonin group were lower than I/R plus saline and differences between the two groups were statistically significant (P < 0.001). GSH levels in the I/R plus saline group decreased significantly when compared with ischemia and sham-operated groups (P < 0.001). GSH levels in the I/R plus melatonin treated rats were significantly higher than I/R plus saline and ischemia groups (P < 0.001). The tissue levels of XO, MDA and GSH were similar between ischemia and ischemia plus melatonin groups. Morphologically, polymorphonuclear neutrophil infiltration and vascular dilatation were obvious in the I/R-damaged ovaries, and the changes also partially reversed by melatonin. This study demonstrates that melatonin protects the ovaries against oxidative damage associated with reperfusion following an ischemic insult.en_US
dc.identifier.doi10.1111/j.1600-079X.2004.00146.x
dc.identifier.endpage141en_US
dc.identifier.issn0742-3098
dc.identifier.issn1600-079X
dc.identifier.issue2en_US
dc.identifier.pmid15298673en_US
dc.identifier.scopus2-s2.0-4344637037en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage137en_US
dc.identifier.urihttps://doi.org/10.1111/j.1600-079X.2004.00146.x
dc.identifier.urihttps://hdl.handle.net/11616/94536
dc.identifier.volume37en_US
dc.identifier.wosWOS:000223156200010en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Pineal Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectmalondialdehydeen_US
dc.subjectmelatoninen_US
dc.subjectovarian torsion/detorsionen_US
dc.subjectraten_US
dc.subjectreduced glutathioneen_US
dc.subjectxanthine oxidaseen_US
dc.titleMelatonin reduces torsion-detorsion injury in rat ovary: biochemical and histopathologic evaluationen_US
dc.typeArticleen_US

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