Increased plasma adrenomedullin levels in patients with Behcet's disease

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dc.authoridYurekli, Muhittin/0000-0002-5830-8564;
dc.authorwosidcekmen, mustafa baki/G-6122-2011
dc.authorwosidYurekli, Muhittin/B-4414-2016
dc.authorwosidEvereklioğlu, Cem/A-5370-2018
dc.contributor.authorEvereklioglu, C
dc.contributor.authorYurekli, M
dc.contributor.authorEr, H
dc.contributor.authorOzbek, E
dc.contributor.authorHazneci, E
dc.contributor.authorCekmen, M
dc.contributor.authorInaloz, HS
dc.date.accessioned2024-08-04T20:12:11Z
dc.date.available2024-08-04T20:12:11Z
dc.date.issued2000
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: Behcet's disease (BD) is a chronic systemic inflammatory disorder affecting multiple organs with a generalized vasculitis of arteries and veins. Endothelial dysfunction is one of the prominent features of ED. Adrenomedullin (AM) is a peptide produced not only in normal adrenal medulla but also in the vascular smooth muscle cells and endothelial cells, and its role in the course of ED has not been previously described. Objective: To detect changes of plasma AM concentrations in patients with ED compared with age- and sex-matched healthy subjects by using high-performance liquid chromatography (HPCL). We also investigated if disease activity or the duration of ED correlates with ANT levels. Methods: Forty-two consecutive patients with ED (38.5 +/- 11.1 years, 19 male and 23 female) and 20 healthy age- and sex-matched control subjects (39.5 +/- 10.9 years, 8 male and 12 female) were included in this study. We measured plasma AM levels by HPCL, and acute-phase reactants including alpha (1)-antitrypsin and alpha (2)-macroglobulin, neutrophil count and the erythrocyte sedimentation rate. Results: Mean +/- SD plasma AM levels in patients with ED (73.22 +/- 25.55 pmol/l) were significantly higher (p < 0.001) than in healthy control volunteers (21.35 12.37 pmol/l). Patients with active ED had similar plasma AM concentrations (79.32 +/- 21.89 pmol/l) with patients with inactive disease (67.44 +/- 29.92 pmol/l). On the other hand, patients with longer duration of the disease (mean duration, 13.9 +/- 3.8 years) had significantly higher plasma AM levels (83.99 +/- 19.71 pmol/l; p = 0.005) than patients (62.45 +/- 26.57 pmol/l) with shorter duration of the disease (mean duration, 5.5 +/- 2.3 years). All acute-phase reaction parameters were found to be significantly increased in the active disease. Conclusion: Considering its endothelial cell implications, AM may be involved in reparatory vessel endothelium mechanisms, especially in the chronic disease. Copyright (C) 2000 S. Karger G, Basel.en_US
dc.identifier.doi10.1159/000051544
dc.identifier.endpage315en_US
dc.identifier.issn1018-8665
dc.identifier.issue4en_US
dc.identifier.pmid11146340en_US
dc.identifier.scopus2-s2.0-0034523878en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage312en_US
dc.identifier.urihttps://doi.org/10.1159/000051544
dc.identifier.urihttps://hdl.handle.net/11616/93272
dc.identifier.volume201en_US
dc.identifier.wosWOS:000166150500006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofDermatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectadrenomedullinen_US
dc.subjectBehcet's diseaseen_US
dc.subjectplasmaen_US
dc.subjectchronicityen_US
dc.titleIncreased plasma adrenomedullin levels in patients with Behcet's diseaseen_US
dc.typeArticleen_US

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