Protective effects of melatonin against 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced cardiac injury in rats

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dc.authoridParlakpinar, Hakan/0000-0001-9497-3468
dc.authoridÇeker, Gökhan/0000-0002-7891-9450
dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authoridYILMAZ, Fethi/0000-0002-5041-9390
dc.authoridCiftci, Osman/0000-0001-5755-3560
dc.authoridSarihan, Mehmet Ediz/0000-0002-1266-4213
dc.authorwosidParlakpinar, Hakan/V-6637-2019
dc.authorwosidÇeker, Gökhan/GPG-3775-2022
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.authorwosidYILMAZ, Fethi/W-9442-2018
dc.authorwosidSarıhan, Mehmet Ediz/JMQ-5971-2023
dc.contributor.authorEdiz, Sarihan Mehmet
dc.contributor.authorHakan, Parlakpinar
dc.contributor.authorOsman, Ciftci
dc.contributor.authorFethi, Yilmaz
dc.contributor.authorMustafa, Sagir
dc.contributor.authorOmur, Yilmaz
dc.contributor.authorGokhan, Ceker
dc.date.accessioned2024-08-04T20:40:21Z
dc.date.available2024-08-04T20:40:21Z
dc.date.issued2015
dc.departmentİnönü Üniversitesien_US
dc.description.abstract2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is the prototype of a group of highly toxic environmental chemicals. Although there are some suggestions regarding TCDD-induced cardio-toxicity, the exact mechanisms underlying this process have not been fully discovered. One mechanism related to this toxicity is believed to be the generation of reactive oxygen species. Melatonin is known to be a strong antioxidant and has a free radical scavenging ability. Therefore, the aim of this study was to investigate the TCDD-induced cardio-toxicity and the protective effects of melatonin in rats. Rats were randomly divided into 4 equal groups (n = 7 for each group). Group 1 was control; group 2 was TCDD group (2 mu g/kg/week, p.o); group 3 was melatonin group (5 mg/kg/day, i.p.) and group 4 was TCDD and melatonin treatment group. All agents were continued to be administered until the 45th day. Body/heart weights, mean oxygen saturation (PO2%), hemodynamic [mean blood pressure (MBP) and heart rate (HR) from the cannulated-carotid artery] and electrocardiographic evaluations (arrhythmias and duration of PR, QRS and QT intervals), biochemical and histopathological analysis were carried out TCDD exposure caused significant body and heart weight loss, impairment of PO2%, and decrease of MBP and HR levels. Also, major ECG changes and prolongation of PR, QRS and QT durations were observed in TCDD-exposed rats. In biochemical analysis, TCDD significantly induced lipid peroxidation and reduced antioxidant activities. Moreover, our histopathological observations were in accordance with the biochemical results. According to the results, melatonin treatment significantly protected the subjects from TCDD-induced cardio-toxicity. (C) 2015 Elsevier B.V. All rights reserved.en_US
dc.identifier.doi10.1016/j.ejphar.2015.04.054
dc.identifier.endpage220en_US
dc.identifier.issn0014-2999
dc.identifier.issn1879-0712
dc.identifier.pmid25962665en_US
dc.identifier.scopus2-s2.0-84937459222en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage214en_US
dc.identifier.urihttps://doi.org/10.1016/j.ejphar.2015.04.054
dc.identifier.urihttps://hdl.handle.net/11616/96869
dc.identifier.volume762en_US
dc.identifier.wosWOS:000359711100026en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofEuropean Journal of Pharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject2,3,7,8-tetrachlorodibenzo-p-dioxinen_US
dc.subjectMelatoninen_US
dc.subjectRaten_US
dc.subjectHearten_US
dc.subjectWasting syndromeen_US
dc.titleProtective effects of melatonin against 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced cardiac injury in ratsen_US
dc.typeArticleen_US

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