Protective Effect of Dexpanthenol on Ischemia-Reperfusion-Induced Liver Injury

Basit Öğe Kaydı
dc.authoridVardı, Nigar/0000-0003-0576-1696
dc.authoridParlakpinar, Hakan/0000-0001-9497-3468
dc.authoridaydogan, mustafa said/0000-0002-7106-1156
dc.authoridUçar, Muharrem/0000-0002-1232-9829
dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authorwosidVardı, Nigar/C-9549-2018
dc.authorwosidParlakpinar, Hakan/V-6637-2019
dc.authorwosidaydogan, mustafa said/AAA-2828-2021
dc.authorwosidUçar, Muharrem/ABH-7761-2020
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.contributor.authorUcar, M.
dc.contributor.authorAydogan, M. S.
dc.contributor.authorVardi, N.
dc.contributor.authorParlakpinar, H.
dc.date.accessioned2024-08-04T20:45:35Z
dc.date.available2024-08-04T20:45:35Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective. We aimed to investigate the protective and therapeutic effects of dexpanthenol (DXP) on liver injuries induced by ischemia-reperfusion (IR) in an in vivo rat model. Methods. Thirty-two rats were randomly divided into 4 experimental groups (n = 8 in each group: Sham, IR, DXP, and DXP+IR. DXP (500 mg/kg) was intraperitoneally administered for 30 min before 60 min of ischemia, followed by 60 min of reperfusion to rats in the DXP and DXP+IR groups. All rats were euthanized on day 10 to evaluate immunohistopathological changes as well as tissue levels of oxidants and antioxidants. Results. IR decreased total glutathione (tGSH) levels in IR group when compared to the Sham group. DXP supplementation to IR group significantly ameliorated tGSH levels (P < .05). IR also elevated myeloperoxidase production compared to the Sham group, whereas DXP treatment prevented these hazardous effects. However, plasma superoxidedismutase, catalase, and malondialdehyde levels did not differ between the DXP+IR than the IR rats. Histologic tissue damage was reduced in the DXP and DXP+IR group. Conclusion. Liver IR is an inevitable problem during liver surgery. Our results suggested that DXP pretreatment suppressed oxidative stress and increased antioxidant levels in a rat model of liver IR.en_US
dc.identifier.doi10.1016/j.transproceed.2018.07.012
dc.identifier.endpage3143en_US
dc.identifier.issn0041-1345
dc.identifier.issn1873-2623
dc.identifier.issue10en_US
dc.identifier.pmid30577179en_US
dc.identifier.scopus2-s2.0-85058548278en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage3135en_US
dc.identifier.urihttps://doi.org/10.1016/j.transproceed.2018.07.012
dc.identifier.urihttps://hdl.handle.net/11616/98576
dc.identifier.volume50en_US
dc.identifier.wosWOS:000454972000037en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofTransplantation Proceedingsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIschemia/Reperfusion Injuryen_US
dc.subjectLipid-Peroxidationen_US
dc.subjectPantothenic-Aciden_US
dc.subjectFree-Radicalsen_US
dc.subjectDamageen_US
dc.titleProtective Effect of Dexpanthenol on Ischemia-Reperfusion-Induced Liver Injuryen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu