Erdosteine prevents doxorubicin-induced cardiotoxicity in rats

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dc.authoridIrmak, M. Kemal/0000-0002-1903-8303
dc.authoridYAGMURCA, MURAT/0000-0001-9774-8151
dc.authorwosidIrmak, M. Kemal/H-6667-2014
dc.authorwosidYAĞMURCA, Murat/AAH-4496-2019
dc.authorwosidFadillioglu, Ersin/K-3817-2019
dc.authorwosidErdogan, Hasan/AFN-9249-2022
dc.authorwosidYAGMURCA, MURAT/A-1851-2018
dc.contributor.authorYagmurca, M
dc.contributor.authorFadillioglu, E
dc.contributor.authorErdogan, H
dc.contributor.authorUcar, M
dc.contributor.authorSogut, S
dc.contributor.authorIrmak, MK
dc.date.accessioned2024-08-04T20:13:26Z
dc.date.available2024-08-04T20:13:26Z
dc.date.issued2003
dc.departmentİnönü Üniversitesien_US
dc.description28th National Congress of Physiology -- SEP 24-27, 2002 -- IZMIR, TURKEYen_US
dc.description.abstractThe clinical use of doxorubicin (Dxr) is limited by its cardiotoxic effects which are mediated by oxygen radicals. The purpose of this study was to investigate in vivo protective effects of erdosteine, an antioxidant agent because of its secondary active metabolites in vivo, against the cardiotoxicity induced by Dxr in rats. Three groups of male Sprague-Dawley rats (60 days old) were used. Group I was untreated group used as control; the other groups were treated with Dxr (single i.p. dosage of 20 mg kg(-1) b.wt.) or Dxr plus erdosteine (10 mg kg(-1) day(-1), orally), respectively. Erdosteine or oral saline treatment was done starting 2 days before Dxr for 12 days. The analyses were done at the 10th day of Dxr treatment. The protein carbonyl content, the activities of myeloperoxidase, aspartate aminotransferase (AST), lactate dehydrogenase (LDH), and creatine kinase (CK) as well as heart rate and blood pressures were significantly increased in Dxr group in comparison with the other groups. However, pulse pressure was decreased in Dxr group. The body and heart weights were decreased in both Dxr administered groups in comparison with control group. Disorganization of myocardial histology, picnotic nuclei, edema, and increase in collagen content around vessels were seen in the slides of Dxr group, whereas normal myocardial microscopy was preserved in Dxr plus erdosteine group. Collectively, these in vivo hemodynamic, enzymatic and morphologic studies provide an evidence for a possible prevention of cardiac toxicity in Dxr-treated patients. (C) 2003 Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/S1043-6618(03)00185-3
dc.identifier.endpage382en_US
dc.identifier.issn1043-6618
dc.identifier.issue4en_US
dc.identifier.pmid12902208en_US
dc.identifier.scopus2-s2.0-0042668482en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage377en_US
dc.identifier.urihttps://doi.org/10.1016/S1043-6618(03)00185-3
dc.identifier.urihttps://hdl.handle.net/11616/93601
dc.identifier.volume48en_US
dc.identifier.wosWOS:000185290600008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAcademic Press Ltd- Elsevier Science Ltden_US
dc.relation.ispartofPharmacological Researchen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectdoxorubicinen_US
dc.subjecterdosteineen_US
dc.subjectprotein carbonylen_US
dc.subjectmyeloperoxidaseen_US
dc.subjectlight microscopyen_US
dc.titleErdosteine prevents doxorubicin-induced cardiotoxicity in ratsen_US
dc.typeConference Objecten_US

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