The Significance of Serum Tumor Markers CEA, Ca 19-9, Ca 125, Ca 15-3, and AFP in Patients Scheduled for Orthotopic Liver Transplantation: Do Elevated Levels Really Mean Malignancy?

Basit Öğe Kaydı
dc.authoridBASKIRAN, ADIL/0000-0002-7536-1631
dc.authoridSarigoz, Talha/0000-0001-6573-6519
dc.authoridYilmaz, Sezai/0000-0002-8044-0297
dc.authorwosidBASKIRAN, ADIL/ABI-2356-2020
dc.authorwosidSarigoz, Talha/H-8727-2019
dc.authorwosidYilmaz, Sezai/ABI-2323-2020
dc.contributor.authorBaskiran, Deniz Yavuz
dc.contributor.authorSarigoz, Talha
dc.contributor.authorBaskiran, Adil
dc.contributor.authorYilmaz, Sezai
dc.date.accessioned2024-08-04T20:51:47Z
dc.date.available2024-08-04T20:51:47Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAim and Background Preparation of the patients for liver transplantation is a meticulous process and includes evaluation of tumor markers to rule out occult malignancy. The present study evaluated the significance of serum tumor markers in patients bound for liver transplantation due to viral and other etiologies of liver failure. Patients and Methods Three hundred eighty-one patients who underwent liver transplantation were included in the study. Demographic data, model for end stage liver disease (MELD) scores, and serum tumor marker levels were prospectively collected. Results AFP levels were significantly higher in viral etiologies when compared to other etiologies (p < 0.05). Ca 19-9 was significantly higher in viral etiologies (p < 0.05). Among the viral etiologies, HCV-related liver failure had higher carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (Ca 19-9) levels (p < 0.05). A correlation was found between increasing MELD scores and serum levels of tumor markers (p < 0.05). Conclusions Tumor markers such as AFP, CEA, Ca 125, and Ca 19-9 can be elevated in end stage liver disease. Their levels vary according to etiology and severity of disease. The diagnostic capabilities of these markers are reduced in end stage liver disease setting but they contribute to the evaluation of the pathophysiology of chronic liver disease. Transplantation can be performed safely in cases with high tumor marker levels provided that any occult malignancy is ruled out by means of imaging and endoscopic techniques. Tumor markers can guide the physician in determining the severity of liver cirrhosis, and further studies are needed to validate such a relationship.en_US
dc.identifier.doi10.1007/s12029-021-00798-5
dc.identifier.endpage446en_US
dc.identifier.issn1941-6628
dc.identifier.issn1941-6636
dc.identifier.issue2en_US
dc.identifier.pmid35312953en_US
dc.identifier.scopus2-s2.0-85126829703en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage442en_US
dc.identifier.urihttps://doi.org/10.1007/s12029-021-00798-5
dc.identifier.urihttps://hdl.handle.net/11616/100553
dc.identifier.volume54en_US
dc.identifier.wosWOS:000771384300001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal of Gastrointestinal Canceren_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChronic liver diseaseen_US
dc.subjectLiver transplantationen_US
dc.subjectHepacivirusen_US
dc.subjectHepatitis B virusen_US
dc.subjectBiomarkersen_US
dc.titleThe Significance of Serum Tumor Markers CEA, Ca 19-9, Ca 125, Ca 15-3, and AFP in Patients Scheduled for Orthotopic Liver Transplantation: Do Elevated Levels Really Mean Malignancy?en_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu