Polyenylphosphatidylcholine pretreatment protects rat liver from ischemia/reperfusion injury

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dc.authoridTurkmen, Samdanci, Emine/0000-0002-0034-5186
dc.authoridGÜRÜNLÜOĞLU, Kubilay/0000-0002-8315-1765
dc.authoridAkin, Melih/0000-0001-9269-8001
dc.authorwosidKARAMAN, Abdurrahman/G-7825-2016
dc.authorwosidTurkmen, Samdanci, Emine/ABH-4716-2020
dc.authorwosidGÜRÜNLÜOĞLU, Kubilay/AAO-5631-2020
dc.contributor.authorDemirbilek, S
dc.contributor.authorKaraman, A
dc.contributor.authorGürünlüoglu, K
dc.contributor.authorTas, E
dc.contributor.authorAkin, M
dc.contributor.authorAksoy, RT
dc.contributor.authorTürkinen, E
dc.date.accessioned2024-08-04T20:15:12Z
dc.date.available2024-08-04T20:15:12Z
dc.date.issued2006
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: Hepatic injury induced by ischemia/reperfusion following surgery, transplantation, or circulatory shock combined with resuscitation is a major clinical problem. Polyenylphosphatidylcholine (PPC) has strong antioxidant, cytoprotective and anti-inflammatory effects. Aim: In this study, the influence of PPC pretreatment on ischemia-reperfusion (I/R) injury of the liver was examined in rats. Methods: The animals were divided into three groups: control (n = 10), I/R (n = 15) and IIR + PPC (n = 15). PPC was given 100 mg/day for 7 days before experiment. Several parameters of hepatic damage, oxidative stress, neutrophil infiltration and nuclear factor kappa beta (NF-kappa B) expression were measured as well as microscopic examination. Results: We observed that a significant reduction in AST and ALT values in the PPC treated group when compared with the ischemic group. The increases in hepatic total NO2 + NO3 and MDA, and decreases in SOD and GSH levels after reperfusion were partially, but significantly, inhibited by PPC pretreatment. I/R induced increase in hepatic myeloperoxidase content and NF-kappa B expression were also lowered by PPC pretreatment. Animals pretreated with PPC presented minimal hemorrhage and reduced signs of liver injury. Conclusion: PPC pretretament provided significant protection againts I/R injury to the liver. This treatment could be therapeutic in liver transplantation and other conditions associated with I/R injury. (c) 2005 Elsevier Ireland Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.hepres.2005.09.040
dc.identifier.endpage91en_US
dc.identifier.issn1386-6346
dc.identifier.issue2en_US
dc.identifier.pmid16406794en_US
dc.identifier.scopus2-s2.0-31344448765en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage84en_US
dc.identifier.urihttps://doi.org/10.1016/j.hepres.2005.09.040
dc.identifier.urihttps://hdl.handle.net/11616/94242
dc.identifier.volume34en_US
dc.identifier.wosWOS:000235502800004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofHepatology Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectliver ischemia/reperfusionen_US
dc.subjectoxidative stressen_US
dc.subjectpolyenylphosphatidylcholineen_US
dc.subjectlecithinen_US
dc.subjecthepatic ischemia/reperfusionen_US
dc.titlePolyenylphosphatidylcholine pretreatment protects rat liver from ischemia/reperfusion injuryen_US
dc.typeArticleen_US

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