The effect of Nigella sativa oil against experimental allergic encephalomyelitis via nitric oxide and other oxidative stress parameters

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dc.contributor.authorOzugurlu, F
dc.contributor.authorSahin, S
dc.contributor.authorIdiz, N
dc.contributor.authorAkyol, O
dc.contributor.authorIlhan, A
dc.contributor.authorYigitoglu, R
dc.contributor.authorIsik, B
dc.date.accessioned2024-08-04T20:15:12Z
dc.date.available2024-08-04T20:15:12Z
dc.date.issued2005
dc.departmentİnönü Üniversitesien_US
dc.description.abstractReactive oxygen species (ROS) including nitric oxide (NO) are thought to be involved in inflammatory processes, exacerbating inflammation and tissue damage in multiple sclerosis (MS). The oil extracts of Nigella Sativa (N. sativa) has been known as an antioxidant and antiinflammatory agent. The aim of the present study was to investigate the hypothesis that N. sativa components provide protection against oxidative stress induced by experimental autoimmune encephalomyelitis (EAE) in rats. For this purpose, EAE was induced in rats by using guinea pig myelin basic protein (MBP) in Freud's adjuvant with addition of heat-killed M. Tuberculosis H37Ra to test this hypohesis. In study groups, N. sativa was given by oral gavage to the rats. Treatment of the rats with N. sativa inhibited ROS production induced by EAE showing diminished levels of MDA of both brain and medulla spinalis tissues. Although there was a significant decrease in brain NO level, there was an increase in medulla spinalis NO level after EAE induction in rats. N. sativa regulated tissue NO levels in some extend when applied together with EAE. When N. sativa was given alone to the rats, no changes were shown in brain, medulla spinalis, and serum oxidant/antioxidant parameters. In conclusion, N sativa may protect brain and medulla spinalis tissues against oxidative stress induced by EAE. In additon, N. sativa display its antioxidant and regulatory effects via inflammatory cells rather than the host tissue (brain and medulla spinalis) for EAE in rats.en_US
dc.identifier.doi10.1170/T635
dc.identifier.endpage342en_US
dc.identifier.issn0145-5680
dc.identifier.issn1165-158X
dc.identifier.issue3en_US
dc.identifier.pmid16191402en_US
dc.identifier.scopus2-s2.0-30744452481en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage337en_US
dc.identifier.urihttps://doi.org/10.1170/T635
dc.identifier.urihttps://hdl.handle.net/11616/94225
dc.identifier.volume51en_US
dc.identifier.wosWOS:000236938600012en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherC M B Assocen_US
dc.relation.ispartofCellular and Molecular Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectmultiple sclerosisen_US
dc.subjectexperimental autoimmune encephalomyelitisen_US
dc.subjectNigella sativaen_US
dc.subjectnitric oxideen_US
dc.subjectoxidantsen_US
dc.subjectantioxidantsen_US
dc.titleThe effect of Nigella sativa oil against experimental allergic encephalomyelitis via nitric oxide and other oxidative stress parametersen_US
dc.typeArticleen_US

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