Alterations in antioxidant enzyme activities in cerebrospinal fluid related with severity of hypoxic ischemic encephalopathy in newborns

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dc.contributor.authorGulcan, H
dc.contributor.authorOzturk, IC
dc.contributor.authorArslan, S
dc.date.accessioned2024-08-04T20:14:56Z
dc.date.available2024-08-04T20:14:56Z
dc.date.issued2005
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground. The antioxidant status of the tissue affected by ischemia-reperfusion is of great importance for the primary endogenous defense against the free-radical-induced injury. Objective: In this study, we aimed to evaluate the relationship between the activities of antioxidant enzymes [superoxide dismutase (SOD), glutathione peroxidase (GPX), and catalase (CAT)] in cerebrospinal fluid (CSF) and severity of hypoxic-ischemic encephalopathy (HIE) in newborns. Methods: Thirty full-term asphyxiated infants (gestational age >37 weeks) and 11 full-term infants (none of whom showed any signs of asphyxia) were included in this study. Activities of SOD, GPX, and CAT in CSF were measured within the first 72 h of life in infants with HIE and controls. Results: Activity of SOD in CSF was significantly higher in infants with HIE compared with controls (p < 0.05). GPX and CAT activities were higher in infants with HIE than they were in controls; however, the differences were not statistically significant (p > 0.05). The activities of GPX and CAT were significantly increased in severe HIE as compared with mild HIE and controls (p < 0.05). Conclusion: Both the duration of the hypoxic-ischemic insult and the severity of HIE modulate elevations of enzymatic activity as an adaptive response to excessive free radical production in CSF in newborn infants with HIE. The activities of antioxidant enzyme alterations in CSIF correspond highly to the severity of HIE, and these patterns may be useful for diagnostic and prognostic purposes. Copyright (C) 2005 S. Karger AG, Basel.en_US
dc.identifier.doi10.1159/000084905
dc.identifier.endpage91en_US
dc.identifier.issn0006-3126
dc.identifier.issue2en_US
dc.identifier.pmid15809502en_US
dc.identifier.scopus2-s2.0-23844525847en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage87en_US
dc.identifier.urihttps://doi.org/10.1159/000084905
dc.identifier.urihttps://hdl.handle.net/11616/94065
dc.identifier.volume88en_US
dc.identifier.wosWOS:000231417600003en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofBiology of The Neonateen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectantioxidant enzyme activityen_US
dc.subjectcerebrospinal fluiden_US
dc.subjecthypoxic ischemic encephalopathyen_US
dc.titleAlterations in antioxidant enzyme activities in cerebrospinal fluid related with severity of hypoxic ischemic encephalopathy in newbornsen_US
dc.typeArticleen_US

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