Multiple PRP injections are more effective than single injections and hyaluronic acid in knees with early osteoarthritis: a randomized, double-blind, placebo-controlled trial

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dc.authoridAslantürk, Okan/0000-0001-6167-3952
dc.authoridAtaoğlu, Baybars/0000-0003-1359-7013
dc.authoridErtem, Kadir/0000-0002-8892-494X
dc.authoridÇOLAK, CEMİL/0000-0001-5406-098X
dc.authorwosidAslantürk, Okan/AAV-8484-2020
dc.authorwosidAtaoğlu, Baybars/AAX-9031-2021
dc.authorwosidErtem, Kadir/ABG-9780-2020
dc.authorwosidÇOLAK, CEMİL/ABI-3261-2020
dc.contributor.authorGormeli, Gokay
dc.contributor.authorGormeli, Cemile Ayse
dc.contributor.authorAtaoglu, Baybars
dc.contributor.authorColak, Cemil
dc.contributor.authorAslanturk, Okan
dc.contributor.authorErtem, Kadir
dc.date.accessioned2024-08-04T20:40:23Z
dc.date.available2024-08-04T20:40:23Z
dc.date.issued2017
dc.departmentİnönü Üniversitesien_US
dc.description.abstractTo compare the effectiveness of intraarticular (IA) multiple and single platelet-rich plasma (PRP) injections as well as hyaluronic acid (HA) injections in different stages of osteoarthritis (OA) of the knee. A total of 162 patients with different stages of knee OA were randomly divided into four groups receiving 3 IA doses of PRP, one dose of PRP, one dose of HA or a saline injection (control). Then, each group was subdivided into two groups: early OA (Kellgren-Lawrence grade 0 with cartilage degeneration or grade I-III) and advanced OA (Kellgren-Lawrence grade IV). The patients were evaluated before the injection and at the 6-month follow-ups using the EuroQol visual analogue scale (EQ-VAS) and International Knee Documentation Committee (IKDC) subjective scores. Adverse events and patient satisfaction were recorded. There was a statistically significant improvement in the IKDC and EQ-VAS scores in all the treatment groups compared with the control group. The knee scores of patients treated with three PRP injections were significantly better than those patients of the other groups. There was no significant difference in the scores of patients injected with one dose of PRP or HA. In the early OA subgroups, significantly better clinical results were achieved in the patients treated with three PRP injections, but there was no significant difference in the clinical results of patients with advanced OA among the treatment groups. The clinical results of this study suggest IA PRP and HA treatment for all stages of knee OA. For patients with early OA, multiple (3) PRP injections are useful in achieving better clinical results. For patients with advanced OA, multiple injections do not significantly improve the results of patients in any group. I.en_US
dc.identifier.doi10.1007/s00167-015-3705-6
dc.identifier.endpage965en_US
dc.identifier.issn0942-2056
dc.identifier.issn1433-7347
dc.identifier.issue3en_US
dc.identifier.pmid26233594en_US
dc.identifier.scopus2-s2.0-84938632901en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage958en_US
dc.identifier.urihttps://doi.org/10.1007/s00167-015-3705-6
dc.identifier.urihttps://hdl.handle.net/11616/96890
dc.identifier.volume25en_US
dc.identifier.wosWOS:000395871800044en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofKnee Surgery Sports Traumatology Arthroscopyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHyaluronic aciden_US
dc.subjectIntraarticular injectionen_US
dc.subjectKnee osteoarthritisen_US
dc.subjectPlatelet-rich plasmaen_US
dc.titleMultiple PRP injections are more effective than single injections and hyaluronic acid in knees with early osteoarthritis: a randomized, double-blind, placebo-controlled trialen_US
dc.typeArticleen_US

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