Activity of Benzimidazole Derivatives and their N-Heterocyclic Carbene Silver Complexes Against Leishmania major Promastigotes and Amastigotes

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dc.authoridGurbuz, Nevin/0000-0003-3201-3597
dc.authorwosidNasr, Ibrahim Al/AFP-8105-2022
dc.authorwosidGurbuz, Nevin/A-3069-2016
dc.contributor.authorKhan, Tariq A.
dc.contributor.authorMnasri, Aziza
dc.contributor.authorAl Nasr, Ibrahim S.
dc.contributor.authorOzdemir, Ismail
dc.contributor.authorGurbuzd, Nevin
dc.contributor.authorHamdi, Naceur
dc.contributor.authorBiersack, Bernhard
dc.date.accessioned2024-08-04T20:51:54Z
dc.date.available2024-08-04T20:51:54Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractLittle progress was conducted concerning discovering new efficient antileishmanial drugs for many years. Hence, the disease has become a global health problem meanwhile. Benzimidazole derivatives and heavy metal complexes have shown potent antiparasitic activities. The present work is intended to evaluate fourteen synthetic benzimidazolium salts and N-heterocyclic silver carbene complexes against Leishmania major. Promastigotes and amastigotes of L. major were cultured in vitro to evaluate compound-induced inhibitory effects, and isolated mouse macrophages were used for cytotoxicity evaluation. Reactive oxygen species (ROS) formation was detected for all compounds as a possible mode of action. The silver complexes 3d and 3e revealed significant activity against L. major promastigotes with IC50 values of 6.4 and 5.5 mu g mL(-1), and SI of 1.77 and 2.02, respectively. Both complexes showed higher ROS production in promastigotes than in macrophages. Further in vivo and enzyme inhibition studies are recommended to evaluate the potential of these compounds as new antileishmanial.en_US
dc.description.sponsorshipDeanship of Scientific Research, Qassim University, Saudi Arabiaen_US
dc.description.sponsorshipThis research is funded by the Deanship of Scientific Research, Qassim University, Saudi Arabia.en_US
dc.identifier.doi10.33263/BRIAC1322.135.135
dc.identifier.issn2069-5837
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85127941004en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.33263/BRIAC1322.135.135
dc.identifier.urihttps://hdl.handle.net/11616/100598
dc.identifier.volume13en_US
dc.identifier.wosWOS:000828471200035en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherAmg Transcend Assocen_US
dc.relation.ispartofBiointerface Research in Applied Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLeishmania majoren_US
dc.subjectN-heterocyclic carbeneen_US
dc.subjectsilver complexesen_US
dc.subjectROS productionen_US
dc.titleActivity of Benzimidazole Derivatives and their N-Heterocyclic Carbene Silver Complexes Against Leishmania major Promastigotes and Amastigotesen_US
dc.typeArticleen_US

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