Melatonin administration prevents the nephrotoxicity induced by gentamicin

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dc.authoridTürköz, Yusuf/0000-0001-5401-0720
dc.authorwosidTürköz, Yusuf/ABG-7931-2020
dc.contributor.authorÖzbek, E
dc.contributor.authorTurkoz, Y
dc.contributor.authorSahna, E
dc.contributor.authorOzugurlu, F
dc.contributor.authorMizrak, B
dc.contributor.authorOzbek, M
dc.date.accessioned2024-08-04T20:12:09Z
dc.date.available2024-08-04T20:12:09Z
dc.date.issued2000
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective To investigate the effect of melatonin on the antioxidant enzyme activity and renal tubular necrosis induced by gentamicin. Materials and methods Twenty-four adult male Sprague-Dawley rats were divided into three equal groups. In group 1, the rats were injected with vehicle (controls), in group 2 they were injected with gentamicin for 5 days and in group 3 injected with gentamicin plus melatonin for 5 days. At 24 h after the last injection, rats were killed and the renal cortex separated from the medulla. Most of the cortex was homogenized but a small sample was fixed in formaldehyde solution for histological examination by light microscopy. Blood samples were also taken to assess the serum levels of urea, creatinine, Na+, K+ and gamma-glutamyl transpeptidase (gamma-GT); before death, urine samples were analysed for protein content. Crude extracts of the cortex were used to deter-mine lipoperoxides, reduced glutathione (GSH-Px), catalase and superoxide dismutase (SOD). The results were compared using the Mann-Whitney U-test. Results Compared with the controls rats, gentamicin caused hyperproteinuria, an increase in the level gamma-GT In serum, a marked increase in lipoperoxides and a signifcant decrease of GSH-Px, catalase and SOD activity in the kidney. In the rats in group 3 there was a marked restoration in lipid peroxidation, GSH-Px, catalase, SOD activity and proteinuria, and in gamma-GT in serum. In rats in group 2 there was widespread tubular necrosis (grade 2-4) but in rats in group 3 there was a merited reduction in the extent of tubular damage. There was no significant difference in serum levels of Na+, K+, blood urea nitrogen and creatinine. Conclusion These results indicate that melatonin prevents the tubular necrosis induced by gentamicin in rats, presumably because it is a potent antioxidant and restores antioxidant enzyme activity in the rat kidney.en_US
dc.identifier.doi10.1046/j.1464-410x.2000.00531.x
dc.identifier.endpage746en_US
dc.identifier.issn1464-4096
dc.identifier.issn1464-410X
dc.identifier.issue6en_US
dc.identifier.pmid10759677en_US
dc.identifier.scopus2-s2.0-0034076071en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage742en_US
dc.identifier.urihttps://doi.org/10.1046/j.1464-410x.2000.00531.x
dc.identifier.urihttps://hdl.handle.net/11616/93252
dc.identifier.volume85en_US
dc.identifier.wosWOS:000086446100030en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofBju Internationalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectgentamicinen_US
dc.subjectnephrotoxicityen_US
dc.subjectmelatoninen_US
dc.subjecttubular necrosisen_US
dc.subjectantioxidant enzymeen_US
dc.titleMelatonin administration prevents the nephrotoxicity induced by gentamicinen_US
dc.typeArticleen_US

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