Role of endometrial concentrations of heavy metals (cadmium, lead, mercury and arsenic) in the aetiology of unexplained infertility

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dc.authoridKaraer, Abdullah/0000-0002-2010-6211
dc.authoridCelik, ebru/0000-0002-0774-4294
dc.authoridOTLU, BARIS/0000-0002-6220-0521
dc.authorwosidKaraer, Abdullah/ABI-4667-2020
dc.authorwosidCelik, ebru/X-4343-2019
dc.authorwosidOTLU, BARIS/ABI-5532-2020
dc.contributor.authorTanrikut, E.
dc.contributor.authorKaraer, A.
dc.contributor.authorCelik, O.
dc.contributor.authorCelik, E.
dc.contributor.authorOtlu, B.
dc.contributor.authorYilmaz, E.
dc.contributor.authorOzgul, O.
dc.date.accessioned2024-08-04T20:39:48Z
dc.date.available2024-08-04T20:39:48Z
dc.date.issued2014
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: To determine the role of endometrial concentrations of heavy metals (cadmium, lead, mercury and arsenic) in the aetiology of unexplained infertility. Study design: Thirty-three women with unexplained infertility and 32 fertile women were recruited. Endometrial biopsies were collected during the putative window of implantation (cycle days 20-24). The concentrations of cadmium, lead, mercury and arsenic were measured in endometrial biopsy specimens using atomic absorption spectrometry. Results: Cadmium was detected in 91% (30/33) of women with unexplained infertility, compared with 34% (11/32) of fertile women. The median endometrial cadmium concentration was 19.58 (interquartile range 1.46-30.23) mu g/l in women with unexplained infertility, compared with 0.00 (interquartile range 0.00-0.40) mu g/l in fertile women. Lead was detected in 15% (5/33) of women with unexplained infertility and 3% (1/32) of fertile women. Mercury and arsenic were not detected in any endometrial samples from either group. Conclusion: A significant difference in endometrial cadmium concentration was found between women with unexplained infertility and fertile women. This suggests that cadmium may be a contributing factor in the aetiology of unexplained infertility. (C) 2014 Elsevier Ireland Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.ejogrb.2014.05.039
dc.identifier.endpage190en_US
dc.identifier.issn0301-2115
dc.identifier.issn1872-7654
dc.identifier.pmid24966000en_US
dc.identifier.scopus2-s2.0-84904615857en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage187en_US
dc.identifier.urihttps://doi.org/10.1016/j.ejogrb.2014.05.039
dc.identifier.urihttps://hdl.handle.net/11616/96510
dc.identifier.volume179en_US
dc.identifier.wosWOS:000340318200035en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofEuropean Journal of Obstetrics & Gynecology and Reproductive Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectArsenicen_US
dc.subjectCadmiumen_US
dc.subjectLeaden_US
dc.subjectMercuryen_US
dc.subjectUnexplained infertilityen_US
dc.titleRole of endometrial concentrations of heavy metals (cadmium, lead, mercury and arsenic) in the aetiology of unexplained infertilityen_US
dc.typeArticleen_US

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