Molsidomine Prevents Cisplatin-induced Hepatotoxicity

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dc.authoridTurkmen, Samdanci, Emine/0000-0002-0034-5186
dc.authoridPolat, Alaadin/0000-0002-6920-3856
dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authoridParlakpinar, Hakan/0000-0001-9497-3468
dc.authoridPolat, Alaadin/0000-0002-6920-3856
dc.authoridSarihan, Mehmet Ediz/0000-0002-1266-4213
dc.authorwosidTurkmen, Samdanci, Emine/ABH-4716-2020
dc.authorwosidBentli, Recep/AAB-4140-2021
dc.authorwosidPolat, Alaadin/AAA-7171-2021
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.authorwosidParlakpinar, Hakan/V-6637-2019
dc.authorwosidPolat, Alaadin/Q-4052-2018
dc.contributor.authorBentli, Recep
dc.contributor.authorParlakpinar, Hakan
dc.contributor.authorPolat, Alaadin
dc.contributor.authorSamdanci, Emine
dc.contributor.authorSarihan, Mehmet Ediz
dc.contributor.authorSagir, Mustafa
dc.date.accessioned2024-08-04T20:37:54Z
dc.date.available2024-08-04T20:37:54Z
dc.date.issued2013
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground and Aims. Despite its beneficial effects, cisplatin has considerable nephrotoxic, ototoxic, neurotoxic and hepatotoxic side effects. It has been documented that reactive oxygen radical species are involved with the pathophysiology of cisplatin-induced hepatotoxicity. Molsidomine (MOL) can exert antioxidant and anti-inflammatory effects. Therefore, the current study was planned to determine the effects of cisplatin on the liver oxidant/antioxidant system and the possible protective effects of (MOL) on liver toxicity. Methods. Animals were divided into four groups as follows: (1) control; (2) MOL; (3) cisplatin and (4) MOL plus cisplatin group. Biochemical and histopathological evaluations were performed on the extracted liver tissue. Also, serum levels of serum aspartate transaminase (AST) and serum alanine transaminase (ALT) were determined. Results. Our results clearly indicated that liver antioxidant enzyme activities and ALT levels were significantly decreased, whereas lipid peroxidation and neutrophil accumulation were increased in the cisplatin-treated animals (5 mg/kg single dose, i.p.) compared to the control rats. MOL treatment (4 mg/kg/day, i.p.) for 3 consecutive days provided a significant protection against cisplatin-induced hazardous changes in the liver tissue. Our histopathological findings including caspase-3 activity were also in accordance with the biochemical results. Conclusions. We propose that MOL acts in the liver as a potent scavenger of free radicals, anti-inflammatory and anti-apoptotic effects to prevent the toxic effects of cisplatin, both at the biochemical and histopathological levels. (C) 2013 IMSS. Published by Elsevier Inc.en_US
dc.identifier.doi10.1016/j.arcmed.2013.09.013
dc.identifier.endpage528en_US
dc.identifier.issn0188-4409
dc.identifier.issn1873-5487
dc.identifier.issue7en_US
dc.identifier.pmid24120390en_US
dc.identifier.scopus2-s2.0-84887161249en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage521en_US
dc.identifier.urihttps://doi.org/10.1016/j.arcmed.2013.09.013
dc.identifier.urihttps://hdl.handle.net/11616/96266
dc.identifier.volume44en_US
dc.identifier.wosWOS:000327416400006en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofArchives of Medical Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCisplatinen_US
dc.subjectMolsidomineen_US
dc.subjectLiveren_US
dc.subjectOxidative stressen_US
dc.titleMolsidomine Prevents Cisplatin-induced Hepatotoxicityen_US
dc.typeArticleen_US

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