Platelet rich plasma application by dermapen microneedling and intradermal point-by-point injection methods, and their comparison with clinical findings and trichoscan in patients with androgenetic alopecia

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dc.authoridAltunisik, Nihal/0000-0001-6844-1097
dc.authoridTürkmen, Dursun/0000-0001-9076-4669
dc.authoridOzcan, Kubra Nur/0000-0002-2854-9551
dc.authorwosidAltunisik, Nihal/ABG-8567-2020
dc.authorwosidTürkmen, Dursun/ABG-3801-2020
dc.contributor.authorOzcan, Kubra Nur
dc.contributor.authorSener, Serpil
dc.contributor.authorAltunisik, Nihal
dc.contributor.authorTurkmen, Dursun
dc.date.accessioned2024-08-04T20:50:52Z
dc.date.available2024-08-04T20:50:52Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAndrogenetic alopecia (AGA) is a progressive hair loss disease that occurs with the effect of androgens and genetic predisposition. Hair thinning and hair loss affect people's self-confidence and self-image more than is thought. In these patients, platelet rich plasma (PRP) treatment is used in addition to the limited medical treatments available. However, there is a lack of standardization for the application method of PRP treatment in the literature. The number of studies in which objective data and hair analysis parameters were revealed to demonstrate the effectiveness of PRP treatment is also very limited. In this study, it was aimed to show the efficacy of PRP treatment with trichoscan data in AGA patients and to compare dermapen-mediated microneedling and point-by-point technique injection application methods. The study was conducted with 62 male AGA patients, aged between 18 and 55 years, who applied to the University Faculty of Medicine, Department of Dermatology, and ranged from Norwood-Hamilton Stage II-V. The patients were randomly divided into two groups and one group was given microneedling with a dermapen, an electrical device that makes automatic needling, and the other group was given manual injection with point-by-point technique with a 30-gauge needle. Before the first treatment, each patient underwent a trichoscan hair analysis evaluation. A total of four sessions of PRP treatment were performed, as three sessions at 2-week intervals and the fourth session 1 month after the last session. The mean age of the cases was 33.13 +/- 6.36. According to Norwood-Hamilton staging, stage III was detected with the highest rate of 46% (29). Hair pulling test became significantly negative after treatment (p < 0.05). Statistically significant differences were found in trichoscan analysis parameters for hair count, hair density, terminal hair count, and terminal hair density in both groups compared to pretreatment (p < 0.05). Between the groups, a statistically significant difference was found between the averages of anagen hair, telogen hair, and hair length in the dermapen treated group compared to the group treated with the point-by-point technique. In our study, the efficacy of PRP treatment for AGA patients was demonstrated by trichoscan parameters. Among the PRP application methods, dermapen-mediated application was found to be superior to the point-by-point technique in terms of anagen, telogen, and average hair length parameters.en_US
dc.identifier.doi10.1111/dth.15182
dc.identifier.issn1396-0296
dc.identifier.issn1529-8019
dc.identifier.issue1en_US
dc.identifier.pmid34714961en_US
dc.identifier.scopus2-s2.0-85119344306en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1111/dth.15182
dc.identifier.urihttps://hdl.handle.net/11616/100316
dc.identifier.volume35en_US
dc.identifier.wosWOS:000718529300001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofDermatologic Therapyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectandrogenetic alopeciaen_US
dc.subjectmicroneedlingen_US
dc.subjectplatelet rich plasmaen_US
dc.subjectpoint by pointen_US
dc.subjecttrichoscanen_US
dc.titlePlatelet rich plasma application by dermapen microneedling and intradermal point-by-point injection methods, and their comparison with clinical findings and trichoscan in patients with androgenetic alopeciaen_US
dc.typeArticleen_US

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