Fish oil protects the peripheral and central nervous systems against cisplatin-induced neurotoxicity

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dc.authoridKamisli, Ozden/0000-0003-1114-7860
dc.authoridKaya, Kürsat/0000-0002-6353-7791
dc.authoridTaşlidere, Aslı Cetin/0000-0003-3902-3210
dc.authoridKamisli, Ozden/0000-0003-1114-7860
dc.authoridKamisli, Suat/0000-0003-4281-3301
dc.authoridCelik, Hamit/0000-0002-8654-2518
dc.authoridCiftci, Osman/0000-0001-5755-3560
dc.authorwosidKamisli, Ozden/JVZ-0145-2024
dc.authorwosidKamisli, Suat/JZT-8388-2024
dc.authorwosidKaya, Kürsat/ABG-2848-2020
dc.authorwosidTaşlidere, Aslı Cetin/AAB-3979-2021
dc.authorwosidKamisli, Ozden/AAA-6553-2020
dc.authorwosidKamisli, Suat/AAC-2706-2021
dc.authorwosidKamisli, Suat/JVN-4663-2024
dc.contributor.authorKamisli, Suat
dc.contributor.authorCiftci, Osman
dc.contributor.authorCetin, Asli
dc.contributor.authorKaya, Kursat
dc.contributor.authorKamisli, Ozden
dc.contributor.authorCelik, Hamit
dc.date.accessioned2024-08-04T20:38:06Z
dc.date.available2024-08-04T20:38:06Z
dc.date.issued2014
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: The protective effects of fish oil (FO) on cisplatin (CP)-induced central and peripheral neurotoxicity were investigated in rats. Methods: Rats (n = 28) were divided equally into four groups, the first group was kept as a control. In the second and third groups, CP and FO were given at doses of 7 mg/kg and 1 softgel/rat/day, respectively. In the fourth group, CP and FO were given together at the same doses. Results: Although CP caused significant oxidative damage, via induction of lipid peroxidation and reduction in the antioxidant defense system potency, FO treatment largely reversed these effects. CP also resulted in histopathological damage, such as apoptosis, and electromyographical changes in the sciatic nerve. FO treatment partially prevented the histopathological and electromyographical effects of CP. Discussion: CP has severe central and peripheral neurotoxic effects in rats and these effects were largely prevented by FO treatment. Thus, it appears that co-administration of FO with CP may be a useful approach to attenuate the negative effects of CP on the nervous system.en_US
dc.identifier.doi10.1179/1476830513Y.0000000074
dc.identifier.endpage126en_US
dc.identifier.issn1028-415X
dc.identifier.issn1476-8305
dc.identifier.issue3en_US
dc.identifier.pmid24112663en_US
dc.identifier.scopus2-s2.0-84897047670en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage116en_US
dc.identifier.urihttps://doi.org/10.1179/1476830513Y.0000000074
dc.identifier.urihttps://hdl.handle.net/11616/96389
dc.identifier.volume17en_US
dc.identifier.wosWOS:000336959500004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherManey Publishingen_US
dc.relation.ispartofNutritional Neuroscienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCisplatinen_US
dc.subjectFish oilen_US
dc.subjectNeuropathyen_US
dc.subjectOxidative damageen_US
dc.subjectElectromyographyen_US
dc.titleFish oil protects the peripheral and central nervous systems against cisplatin-induced neurotoxicityen_US
dc.typeArticleen_US

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