Effects of thymoquinone and curcumin on the regeneration of rat livers subject to 70% hepatectomy

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dc.authoridbardakçı, Osman/0000-0003-0067-3451
dc.authoridYILMAZ, Mehmet/0000-0002-5710-5263;
dc.authorwosidbardakçı, Osman/HZJ-3644-2023
dc.authorwosidYILMAZ, Mehmet/HKM-4739-2023
dc.authorwosidGozeneli, Orhan/AAM-7891-2021
dc.authorwosidTaşkın, Abdullah/ABF-5740-2020
dc.authorwosidYilmaz, Mehmet/AAF-6095-2021
dc.authorwosidGUNES, ALI ERDAL/ABF-3292-2020
dc.authorwosidTatlı, Faik/ABH-7308-2020
dc.contributor.authorGozeneli, Orhan
dc.contributor.authorTatli, Faik
dc.contributor.authorGunes, Ali Erdal
dc.contributor.authorGuldur, Muhammed Emin
dc.contributor.authorTaskin, Abdullah
dc.contributor.authorBardakci, Osman
dc.contributor.authorYilmaz, Mehmet
dc.date.accessioned2024-08-04T20:44:19Z
dc.date.available2024-08-04T20:44:19Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPurpose: To investigate thymoquinone, curcumin and a combination of these two drugs were effective or not at the growth of liver. Methods: Forty female Wistar-Albino rats distributed into five groups of eight rats each, control, thymoquinone, curcumin, and thymoquinone/curcumin groups. Pathological specimens were studied using the Ki-67 Proliferation Index(PI); and arginase(Arg), tissue plasminogen activator(tPA), ceruloplasmin(Cer) and nitric oxide(NO) were studied in biochemical analysis. Results: Our results showed that Ki-67 proliferation index was low in Groups 1. The proliferation coefficient was significantly higher in the Group 2 and Group 4 than in the Group 1 and Group 3.(P < 0.001 between Groups 1 and 2, 1 and 4, and 3 and 4). There was no difference between Groups 2 and 4 (P = 1). The results of the biochemical Arg, tPA and Cer test showed statistically between the Group 1 and Group 2. NO showed significant differences Group 1 and 3. Conclusions: Thymoquinone and curcumin both have known positive effects on the organism. Histological and biochemical tests showed that thymoquinone is more effective than curcumin.en_US
dc.description.sponsorshipT C Harran University Council of Scientific Research [15115]en_US
dc.description.sponsorshipT C Harran University Council of Scientific Research (Project no 15115)en_US
dc.identifier.doi10.1590/s0102-865020180020000002
dc.identifier.endpage116en_US
dc.identifier.issn0102-8650
dc.identifier.issn1678-2674
dc.identifier.issue2en_US
dc.identifier.pmid29513809en_US
dc.identifier.scopus2-s2.0-85042910671en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage110en_US
dc.identifier.urihttps://doi.org/10.1590/s0102-865020180020000002
dc.identifier.urihttps://hdl.handle.net/11616/98179
dc.identifier.volume33en_US
dc.identifier.wosWOS:000426974600002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherActa Cirurgica Brasileiraen_US
dc.relation.ispartofActa Cirurgica Brasileiraen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCurcuminen_US
dc.subjectThymoquinoneen_US
dc.subjectHepatectomyen_US
dc.subjectLiver Regenerationen_US
dc.subjectKi-67 Antigenen_US
dc.subjectRatsen_US
dc.titleEffects of thymoquinone and curcumin on the regeneration of rat livers subject to 70% hepatectomyen_US
dc.typeArticleen_US

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