Antimicrobial Resistance and Molecular Epidemiology of Corynebacterium striatum Isolated in a Tertiary Hospital in Turkey

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dc.authoridOTLU, BARIS/0000-0002-6220-0521
dc.authorwosidOTLU, BARIS/ABI-5532-2020
dc.contributor.authorAsgin, Nergis
dc.contributor.authorOtlu, Baris
dc.date.accessioned2024-08-04T20:47:08Z
dc.date.available2024-08-04T20:47:08Z
dc.date.issued2020
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAlthough Corynebacterium striatum is part of the human flora, it has recently drawn attention both for its multidrug resistance and its role as an invasive infection/outbreak agent. This cross-sectional study aimed to determine the antimicrobial resistance and clonal relationships among C. striatum strains. In total, 81 C. striatum strains were identified using Phoenix-100(TM) (BD, Sparks, MD, USA). The antimicrobial resistance of the strains was determined using the Kirby-Bauer disk diffusion method. Clonal relatedness among the strains was performed via arbitrarily primed polymerase chain reaction (AP-PCR). All 81 C. striatum strains were resistant to penicillin, cefotaxime, ciprofloxacin, and tetracycline, but susceptible to vancomycin and linezolid. The resistance rates to gentamicin, erythromycin, and clindamycin were 34.6%, 79%, and 87.7% respectively. AP-PCR results showed no predominant clone among the C. striatum strains. Corynebacterium striatum is reportedly the cause of an increasing number of invasive infections/outbreaks. Moreover, treatment options are limited. The study showed that vancomycin, linezolid, and gentamicin can be selected for the empirical treatment of C. striatum infections. Although no single-clone outbreak was observed in our hospital, small clonal circulations were observed within some units, indicating cross-contamination. Therefore, a comprehensive infection control program is warranted in future.en_US
dc.identifier.doi10.3390/pathogens9020136
dc.identifier.issn2076-0817
dc.identifier.issue2en_US
dc.identifier.pmid32093060en_US
dc.identifier.scopus2-s2.0-85079705767en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.3390/pathogens9020136
dc.identifier.urihttps://hdl.handle.net/11616/99187
dc.identifier.volume9en_US
dc.identifier.wosWOS:000519242900024en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMdpien_US
dc.relation.ispartofPathogensen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectantimicrobial resistanceen_US
dc.subjectarbitrarily primed polymerase chain reactionen_US
dc.subjectcloneen_US
dc.subjectCorynebacterium striatumen_US
dc.subjectmolecular epidemiologyen_US
dc.subjectnosocomial outbreaken_US
dc.titleAntimicrobial Resistance and Molecular Epidemiology of Corynebacterium striatum Isolated in a Tertiary Hospital in Turkeyen_US
dc.typeArticleen_US

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