Vascular complications and associated comorbidities in newly diagnosed pre-diabetes: is it the tip of the iceberg?

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dc.authoridgenç, selin/0000-0001-5525-3476
dc.authorwosidCankaya, Cem/HTR-3803-2023
dc.authorwosidgenç, selin/ABP-1598-2022
dc.contributor.authorGenc, S.
dc.contributor.authorEvren, B.
dc.contributor.authorCankaya, C.
dc.contributor.authorTecellioglu, M.
dc.contributor.authorBozbay, A.
dc.contributor.authorYavuz, A. O.
dc.contributor.authorAykac, K. N.
dc.date.accessioned2024-08-04T20:54:39Z
dc.date.available2024-08-04T20:54:39Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractOBJECTIVE: The aim of this study was to investigate the prevalence of microvascular and macrovascular diabetic complications and the associated comorbidities in newly diagnosed pre-diabetic individuals. PATIENTS AND METHODS: This cross-sectional study includes 100 newly diagnosed pre-diabetic individuals. Fasting plasma glucose, HbA1c, and oral glucose tolerance (OGTT) were tested according to the American Diabetes Association's diagnostic criteria for pre-diabetes, besides anthropometric measurements, lipid profiles, and demographic and biochemical parameters. Comorbidities like hypertension, obesity, dyslipidemia etc., were evaluated. All participants were screened for microvascular (retinopathy, nephropathy, neuropathy) and macrovascular [coronary artery disease (CAD) and cerebrovascular event-peripheral artery disease] complications. RESULTS: Microvascular complications were found in 12% of the participants (neuropathy: 4%, nephropathy: 8%) and 19% had macrovascular complications. Of the participants, 21% of the cases presented hypertension, 21% dyslipidemia and 48% obesity. A high probability of developing non-alcoholic fatty liver disease- related fibrosis [estimated using non-alcoholic fatty liver disease fibrosis score (NFS)] was found in 68% of cases. History of dyslipidemia (OR: 5.00, 95% CI: 1.10-22.56; p = 0.037) was an independent risk factor for the development of vascular complications. CONCLUSIONS: Diabetic vascular complications were found in approximately one-third of pre-diabetic cases. Dyslipidaemia was found to be an important risk factor for the development of vascular complications in these individuals.en_US
dc.identifier.endpage7568en_US
dc.identifier.issn1128-3602
dc.identifier.issue16en_US
dc.identifier.pmid37667932en_US
dc.identifier.scopus2-s2.0-85169847512en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage7557en_US
dc.identifier.urihttps://hdl.handle.net/11616/101559
dc.identifier.volume27en_US
dc.identifier.wosWOS:001076331800017en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherVerduci Publisheren_US
dc.relation.ispartofEuropean Review For Medical and Pharmacological Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPrediabetesen_US
dc.subjectDiabetic complicationsen_US
dc.subjectMicrovascularen_US
dc.subjectMacrovascularen_US
dc.subjectComorbiditiesen_US
dc.subjectRisk factorsen_US
dc.titleVascular complications and associated comorbidities in newly diagnosed pre-diabetes: is it the tip of the iceberg?en_US
dc.typeArticleen_US

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