Novel 1,2,4-Triazolo[3,4-b]-1,3,4-thiadiazole Derivatives as Dual Analgesic/Anti-inflammatory and Antimicrobial Agents

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dc.authoridGünal, Selami/0000-0002-4752-5176
dc.authoridAKTAY, Goknur/0000-0002-1646-8674
dc.authorwosidGürsoy, Şule/JPW-8593-2023
dc.authorwosidGünal, Selami/AAA-7246-2021
dc.authorwosidAytac, Peri/AGY-9153-2022
dc.contributor.authorTozkoparan, Birsen
dc.contributor.authorAytac, Sevim Peri
dc.contributor.authorGursoy, Sule
dc.contributor.authorGunal, Selami
dc.contributor.authorAktay, Goknur
dc.date.accessioned2024-08-04T20:35:48Z
dc.date.available2024-08-04T20:35:48Z
dc.date.issued2012
dc.departmentİnönü Üniversitesien_US
dc.description.abstractFor this study, a series of 3,6-disubstituted-1,2,4-triazolo-[3,4-b]-1,3,4-thiadiazoles (1-12) were synthesized by condensation of 4-amino-5-substituted-3-mercapto-1,2,4-triazoles with various benzoic acids through a one-pot reaction. The anti-inflammatory and analgesic activities as well as gastrointestinal irritation liability of the obtained compounds were evaluated. Several of the synthesized compounds showed noticeable analgesic and anti-inflammatory activity. For the active compounds a very low ulcerogenic index and diminished oxidative damage in stomach were observed. Moreover, title compounds were screened for their antifungal and antibacterial activities. Antifungal activity of the compounds was found better than that of their antibacterial activity.en_US
dc.identifier.doi10.2174/157018012799079626
dc.identifier.endpage212en_US
dc.identifier.issn1570-1808
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-84858165442en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage204en_US
dc.identifier.urihttps://doi.org/10.2174/157018012799079626
dc.identifier.urihttps://hdl.handle.net/11616/95595
dc.identifier.volume9en_US
dc.identifier.wosWOS:000300610600010en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherBentham Science Publ Ltden_US
dc.relation.ispartofLetters in Drug Design & Discoveryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject4-Amino-3-mercapto-1,2,4-triazoleen_US
dc.subjectAnalgesic activityen_US
dc.subjectAnti-inflammatory activityen_US
dc.subjectAntimicrobial activityen_US
dc.subjectAntioxidant activityen_US
dc.subject1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoleen_US
dc.titleNovel 1,2,4-Triazolo[3,4-b]-1,3,4-thiadiazole Derivatives as Dual Analgesic/Anti-inflammatory and Antimicrobial Agentsen_US
dc.typeArticleen_US

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