Quercetin Exhibits Nephroprotective Properties Against Tartrazine-Induced Nephrotic Injury: Effects on Oxidative Stress, Kidney Function, Inflammation, Renal Tissue Morphology, and Apoptotic Pathway

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dc.contributor.authorErdemli, Zeynep
dc.contributor.authorGul, Mehmet
dc.contributor.authorBulut, Nilufer
dc.contributor.authorZayman, Emrah
dc.contributor.authorDemirtas, Sezin
dc.contributor.authorKaraaslan, Ezgi
dc.contributor.authorAylaz, Bulent
dc.date.accessioned2026-04-04T13:37:38Z
dc.date.available2026-04-04T13:37:38Z
dc.date.issued2026
dc.departmentİnönü Üniversitesi
dc.description.abstractWe investigated first time in the literature the effects of tartrazine, a common industrial dye, and quercetin, a possible protective, on the kidneys. The rats were randomly assigned to the control, tartrazine, quercetin, and tartrazine + quercetin groups, with each group consisting of eight Wistar albino rats. The trials lasted for 1 month, after which kidney tissues and blood samples were collected. In the tartrazine group, increases were observed in malondialdehyde (MDA), superoxide dismutase (SOD), total oxidant status (TOS), oxidative stress index (OSI), tumor necrosis factor alpha (TNF-alpha), interleukin-6 (IL-6), glomerular diameter and damage, histopathological damage score, glomerular and tubular caspase-3 immunoreactivity H-score, as well as serum urea, uric acid, and creatinine levels in the kidney tissue. Additionally, kidney tissue histopathology and apoptotic deteriorated in the same group. The deteriorated biochemical and histopathological parameters improved with quercetin administration. Tartrazine led to nephrotoxicity in rats, as indicated by kidney tissue oxidant capacity, inflammation, apoptosis, increased kidney function tests, and deterioration in histopathology. Quercetin exhibited strong antioxidant, antiapoptotic, and anti-inflammation activity and can be used as a protective agent against tartrazine-induced nephrotoxicity.
dc.description.sponsorshipInonu University Scientific Research Fund [TSA-2024-3701]
dc.description.sponsorshipWe would like to thank Inonu University Scientific Research Projects Unit for supporting our work. This research was supported by the Inonu University Scientific Research Fund (TSA-2024-3701).
dc.identifier.doi10.1002/jbt.70691
dc.identifier.issn1095-6670
dc.identifier.issn1099-0461
dc.identifier.issue1
dc.identifier.pmid41521520
dc.identifier.scopus2-s2.0-105027171517
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1002/jbt.70691
dc.identifier.urihttps://hdl.handle.net/11616/109957
dc.identifier.volume40
dc.identifier.wosWOS:001659148400001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of Biochemical and Molecular Toxicology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250329
dc.subjectapoptosis
dc.subjectinflammation
dc.subjectnephrotoxicity
dc.subjectoxidative stress
dc.subjectquercetin
dc.subjecttartrazine
dc.titleQuercetin Exhibits Nephroprotective Properties Against Tartrazine-Induced Nephrotic Injury: Effects on Oxidative Stress, Kidney Function, Inflammation, Renal Tissue Morphology, and Apoptotic Pathway
dc.typeArticle

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