The effects of remifentanil and alfentanil-based total intravenous anesthesia (TIVA) on the endocrine response to abdominal hysterectomy

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dc.authoridGanidagli, Suleyman/0000-0002-9644-7688
dc.authorwosidGanidagli, Suleyman/AAV-2436-2021
dc.contributor.authorDemirbilek, S
dc.contributor.authorGanidagli, S
dc.contributor.authorAksoy, N
dc.contributor.authorBecerik, C
dc.contributor.authorBaysal, Z
dc.date.accessioned2024-08-04T20:30:51Z
dc.date.available2024-08-04T20:30:51Z
dc.date.issued2004
dc.departmentİnönü Üniversitesien_US
dc.description.abstractStudy Objective: To compare the effects of remifentanil with alfentanil as a part of total intravenous anesthesia (TIVA) on plasma concentrations of cortisol, insulin, and glucose, and hemodynamic responses in patients undergoing abdominal hysterectomy. Design: Randomized, double-blind study. Setting: University hospital. Patients: 24 ASA physical status I female patients scheduled for abdominal hysterectomy. Interventions: Premedicated patients were randomly allocated to receive either remifentanil-propofol (Group R) or a (alfentanil-propofol (Group A). The loading dose of the study drug was administered over 60 seconds (remifentanil l mug kg(-l) or alfentanil 10 mug kg(-l)) followed by a continuous infusion (remifentanil 0.2 mug kg(-l) min(-l) or a fentanil 0.5 mug kg(-l) min). In both groups, propofol was administered until loss of consciousness and maintained with a propofol infusion rate of 100 mug kg(-l) min(-l). After induction of anesthesia, all patients were manually ventilated by mask with O-2-air mixture for 20 minutes. Then rocuronium 0.6 mg kg(-l) was given for tracheal intubation. Measurements: Mean arterial pressure (MAP) and heart rate (HR) were recorded. Plasma concentrations of cortisol, insulin, and glucose were measured during anesthesia and in the recovery room. Main Results: In Group R, MAP and HR were lower after tracheal intubation and skin incision than in Group A (p < 0.05). Plasma cortisol concentrations decreased from baseline values at 20 minutes after induction, after tracheal intubation, and skin incision in Group R (p < 0.001). Plasma concentrations of cortisol and glucose increased from baseline values at 30 minutes after skin incision and continued to increase in both groups (p = 0.001). Plasma concentrations of cortisol, insulin, and glucose did not differ between groups at all sampling times. Conclusion: Remifentanil provided better hemodynamic stability than alfentanil during anesthesia and surgery. However, both remifentanil and alfentanil had similar effects on the stress endocrine response to abdominal hysterectomy. (C) 2004 by Elsevier Inc.en_US
dc.identifier.doi10.1016/j.jclinane.2003.10.002
dc.identifier.endpage363en_US
dc.identifier.issn0952-8180
dc.identifier.issue5en_US
dc.identifier.pmid15374557en_US
dc.identifier.scopus2-s2.0-4544328744en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage358en_US
dc.identifier.urihttps://doi.org/10.1016/j.jclinane.2003.10.002
dc.identifier.urihttps://hdl.handle.net/11616/94571
dc.identifier.volume16en_US
dc.identifier.wosWOS:000224227000008en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofJournal of Clinical Anesthesiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectanestheticen_US
dc.subjectpropololen_US
dc.subjectremifentanilen_US
dc.subjectalfentanilen_US
dc.subjectstress responseen_US
dc.subjectcortisolen_US
dc.subjectglucoseen_US
dc.subjecttotal intravenous anesthesiaen_US
dc.titleThe effects of remifentanil and alfentanil-based total intravenous anesthesia (TIVA) on the endocrine response to abdominal hysterectomyen_US
dc.typeArticleen_US

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