COPET study findings regarding the clinical relevance of biomass exposure as an etiotype in COPD

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dc.contributor.authorYazar, Esra Ertan
dc.contributor.authorDemirci, Nilgun
dc.contributor.authorYigitbas, Burcu Arpinar
dc.contributor.authorCalikoglu, Mukadder
dc.contributor.authorGulbas, Gazi
dc.contributor.authorTuran, Muzaffer Onur
dc.contributor.authorSahin, Hulya
dc.date.accessioned2026-04-04T13:35:13Z
dc.date.available2026-04-04T13:35:13Z
dc.date.issued2025
dc.departmentİnönü Üniversitesi
dc.description.abstractPurpose: The finding that COPD can also develop in non-smokers has led to further investigations of etiologic causes other than smoking. This study evaluated the relationship between tobacco smoking and/or biomass-burning smoke exposure (BBS) and the demographic, clinical, and prognostic characteristics of individuals with COPD. Methods; A total of 1129 stable COPD patients from the COPET study were retrospectively analyzed. The patients were divided into three groups: the COPD-B group (n = 52), which included patients who were solely BBS; the COPD-C group (n = 634), which included patients who exclusively tobacco smoking; and the COPD-BC group (n = 443), which included patients with both BBS and tobacco smoking. Results: The average age of the patients was 65.8 +/- 9.1 years, and 87.4 % of them were men. In the COPD-B group, the following factors were significantly greater compared to the COPD-C and COPD-BC groups: age (p = 0.001), BMI (p = 0.001), percentage of female patients (p < 0.001), FEV1/FVC ratio (p = 0.014), eosinophil count (p < 0.001), ADO score (p < 0.001), and the proportion of patients with frequent exacerbations (p = 0.013). Thorax CT scans showed that the COPD-BC group had a greater incidence of bronchiectasis and emphysema than the COPD-B and COPD-C groups (p < 0.001). Conclusions: This study highlights significant clinical and radiological differences among COPD patients based on tobacco smoking and BBS, which may substantially impact COPD outcomes, including exacerbations and prognosis.
dc.identifier.doi10.1016/j.amjms.2025.07.001
dc.identifier.endpage370
dc.identifier.issn0002-9629
dc.identifier.issn1538-2990
dc.identifier.issue4
dc.identifier.orcid0000-0003-0692-4784
dc.identifier.orcid0000-0002-0780-6176
dc.identifier.pmid40645336
dc.identifier.scopus2-s2.0-105012743383
dc.identifier.scopusqualityQ1
dc.identifier.startpage365
dc.identifier.urihttps://doi.org/10.1016/j.amjms.2025.07.001
dc.identifier.urihttps://hdl.handle.net/11616/109704
dc.identifier.volume370
dc.identifier.wosWOS:001584477800010
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Science Inc
dc.relation.ispartofAmerican Journal of the Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250329
dc.subjectNon-smokers
dc.subjectBiomass
dc.subjectChronic obstructive pulmonary disease
dc.subjectEtiotypes
dc.subjectTaxonomy
dc.titleCOPET study findings regarding the clinical relevance of biomass exposure as an etiotype in COPD
dc.typeArticle

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