The effects of dexmedetomidine on liver ischemia-reperfusion injury in rats

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dc.authoridPolat, Alaadin/0000-0002-6920-3856
dc.authoridDurmus, Mahmut/0000-0001-9594-9064
dc.authoridbegeç, zekine/0000-0002-9506-1871
dc.authoridŞahin, Taylan/0000-0002-9888-6625
dc.authoridYücel, Aytaç/0000-0003-0270-8339
dc.authoridErsoy, Mehmet/0000-0002-0724-2825
dc.authoridPolat, Alaadin/0000-0002-6920-3856
dc.authorwosidPolat, Alaadin/Q-4052-2018
dc.authorwosidsahin, taylan/IWD-9406-2023
dc.authorwosidDurmus, Mahmut/ABH-3006-2020
dc.authorwosidbegeç, zekine/ABI-5491-2020
dc.authorwosidŞahin, Taylan/AAT-4038-2020
dc.authorwosidYücel, Aytaç/ABI-6137-2020
dc.authorwosidErsoy, Mehmet/ACN-2779-2022
dc.contributor.authorSahin, Taylan
dc.contributor.authorBegec, Zekine
dc.contributor.authorToprak, Huseyin I.
dc.contributor.authorPolat, Alaadin
dc.contributor.authorVardi, Nigar
dc.contributor.authorYucel, Aytac
dc.contributor.authorDurmus, Mahmut
dc.date.accessioned2024-08-04T20:37:41Z
dc.date.available2024-08-04T20:37:41Z
dc.date.issued2013
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: Ischemia-reperfusion (IR) injury of the liver may cause various types of damage to hepatic tissues. It can affect the prognosis of patients and the success of an operation. Dexmedetomidine is a selective alpha(2) receptor agonist. We investigated whether dexmedetomidine provides protection against IR-induced liver injury in rats. Methods: Forty rats were divided equally into four groups. In group 1, the liver was manipulated after the laparotomy, and no occlusion of the vessels of the liver was performed. In group 2, once the abdomen was opened, 60 min of ischemia and 60 min of reperfusion were applied according to the segmental hepatic ischemia model. In group 3, 10 mu g/kg of dexmedetomidine was injected into the peritoneal cavity 30 min before ischemia. In group 4, 100 mu g/kg of dexmedetomidine was injected into the peritoneal cavity 30 min before ischemia. Further procedures in groups 3 and 4 were the same as those of group 2. After the experiment was completed, the rats were killed. Liver tissues were removed and stored until biochemical and histologic assessments were performed. Results: The malondialdehyde level in group 2 was higher than that of groups 1, 3, and 4 (P = 0.001, P = 0.000, and P = 0.000, respectively). Superoxide dismutase, catalase, and glutathione levels in group 2 were lower than those in group 1 (P = 0.001, P = 0.027, and P = 0.014, respectively). Superoxide dismutase and catalase levels in group 4 were higher than those in group 2 (P = 0.002 and P = 0.000, respectively). GSH levels in groups 3 and 4 were higher than those in group 2 (P = 0.049 and P = 0.006, respectively). A lower glutathione peroxidase level was detected in groups 2 and 3 than that in group 1 (P = 000). Group 4 demonstrated an increase in glutathione peroxidase levels compared with group 3 (P = 0.014). The histologic injury scores in groups 2-4 were higher than those in group 1 (P = 0.003, P = 0.002, and P = 0.001, respectively). However, the histologic injury scores were lower in groups 3 and 4 than those in group 2 (P = 0.003 and P = 0.002, respectively). Conclusions: This study showed that dexmedetomidine may protect the liver against IR injury in rats. (C) 2013 Elsevier Inc. All rights reserved.en_US
dc.description.sponsorshipInonu University Department of Scientific Research [2010/139]en_US
dc.description.sponsorshipThis study was supported by Inonu University Department of Scientific Research Projects (Project no: 2010/139).en_US
dc.identifier.doi10.1016/j.jss.2012.11.034
dc.identifier.endpage390en_US
dc.identifier.issn0022-4804
dc.identifier.issn1095-8673
dc.identifier.issue1en_US
dc.identifier.pmid23321519en_US
dc.identifier.scopus2-s2.0-84879074759en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage385en_US
dc.identifier.urihttps://doi.org/10.1016/j.jss.2012.11.034
dc.identifier.urihttps://hdl.handle.net/11616/96099
dc.identifier.volume183en_US
dc.identifier.wosWOS:000320599600056en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAcademic Press Inc Elsevier Scienceen_US
dc.relation.ispartofJournal of Surgical Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLiveren_US
dc.subjectIschemia-reperfusionen_US
dc.subjectInjuryen_US
dc.subjectDexmedetomidineen_US
dc.titleThe effects of dexmedetomidine on liver ischemia-reperfusion injury in ratsen_US
dc.typeArticleen_US

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