Analysis of risk factors affecting the development of peptic ulcer perforation: case-control study

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dc.authoridAkbulut, Sami/0000-0002-6864-7711
dc.authoridYilmaz, Sezai/0000-0002-8044-0297
dc.authoridDemyati, Khaled/0000-0002-9591-2664
dc.authoridKoc, Cemalettin/0000-0002-5676-6772
dc.authorwosidAkbulut, Sami/L-9568-2014
dc.authorwosidYilmaz, Sezai/ABI-2323-2020
dc.authorwosidKoc, Cemalettin/B-6430-2018
dc.contributor.authorAkbulut, Sami
dc.contributor.authorCaliskan, Ali Riza
dc.contributor.authorSaritas, Hasan
dc.contributor.authorDemyati, Khaled
dc.contributor.authorBilgic, Yilmaz
dc.contributor.authorUnsal, Selver
dc.contributor.authorKoc, Cemalettin
dc.date.accessioned2024-08-04T20:50:13Z
dc.date.available2024-08-04T20:50:13Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAim: The aim of the to determine the risk factors associated with increased risk of peptic ulcer perforation (PUP). Material and methods: The demographic, clinic, and biochemical parameters of 65 patients (PUP group) who underwent PUP surgery at our clinic between June 2009 and September 2016 were compared with the data of 134 patients (control group) who underwent endoscopy at a gastroenterology clinic for dyspeptic complaints. The control group were matched at random in a 1 : 2 ratio with the PUP group. Univariate analyses were used to compare different variables and variables with clinical significance, and p <= 0.05 was used in the backward stepwise logistic regression model. Results: This study included 65 patients with peptic ulcer perforation aged 17 to 92 years (PUP group) and 134 patients with dyspeptic complaints aged 18 to 87 years (control group). Univariate analysis showed that statistically significant differences were found between groups in terms of non-steroidal anti-inflammatory drugs usage (p = 0.042; OR = 1.868), smoking (p < 0.001; OR = 5.124), old age (p = 0.003), low body mass index (BMI) (p < 0.001), and low hemoglobin (Hb) (p = 0.002). However multivariate analysis showed that increasing age (p = 0.004; OR = 1.035), smoking (p = 0.007; OR = 3.591), decreasing Hb (p = 0.042; OR = 1.277), and decreasing BMI (p < 0.001; OR = 1.669) were independent clinically significant risk factors for development of PUP. Conclusions: This study showed that decreased BMI, decreased Hb, increased age, and smoking were independent risk factors for development of PUP. Thus, this group of patients needs particular attention paid to suggestive symptoms with early diagnosis and optimal management of peptic ulcer disease.en_US
dc.identifier.doi10.5114/pg.2020.94744
dc.identifier.endpage28en_US
dc.identifier.issn1895-5770
dc.identifier.issn1897-4317
dc.identifier.issue1en_US
dc.identifier.pmid33986884en_US
dc.identifier.scopus2-s2.0-85105304305en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage23en_US
dc.identifier.urihttps://doi.org/10.5114/pg.2020.94744
dc.identifier.urihttps://hdl.handle.net/11616/99911
dc.identifier.volume16en_US
dc.identifier.wosWOS:000635184700006en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTermedia Publishing House Ltden_US
dc.relation.ispartofGastroenterology Review-Przeglad Gastroenterologicznyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectpeptic ulceren_US
dc.subjectperforationen_US
dc.subjectrisk factorsen_US
dc.titleAnalysis of risk factors affecting the development of peptic ulcer perforation: case-control studyen_US
dc.typeArticleen_US

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