Medical ozone treatment ameliorates the acute distal colitis in rats

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dc.authoridavcı, sema/0000-0002-2860-5592
dc.authoridSoylu, Hakan/0000-0002-1177-2351
dc.authoridTekeli, Seckin Ozgur/0000-0002-4430-1134
dc.authoridCakir, Tugrul/0000-0001-7952-8462
dc.authorwosidavcı, sema/I-8850-2017
dc.authorwosidUstunel, İsmail/I-8932-2017
dc.authorwosidAkyüz, Cebrail/AGY-4201-2022
dc.authorwosidÇakır, Tuğrul/AAD-1906-2019
dc.authorwosidAslaner, Arif/AAH-9024-2020
dc.authorwosidSoylu, Hakan/I-8911-2017
dc.contributor.authorAslaner, Arif
dc.contributor.authorCakir, Tugrul
dc.contributor.authorTekeli, Seckin Ozgur
dc.contributor.authorAvci, Sema
dc.contributor.authorDogan, Ugur
dc.contributor.authorTekeli, Feyza
dc.contributor.authorSoylu, Hakan
dc.date.accessioned2024-08-04T20:41:45Z
dc.date.available2024-08-04T20:41:45Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPURPOSE: To investigate the effect of medical ozone treatment on the experimental acute distal colitis in rats. METHODS: Eighteen rats were randomly distributed into three equal groups; control, acute distal colitis (ADC) without and with medical ozone treatment. Rats in the control group were taken saline. ADC was performed by rectal way with 4% acetic acid in groups 2 and 3, and the group 3 was treated with medical ozone for three weeks both rectally and intraperitoneally. At the twenty second day the distal colons samples were obtained for malondialdehyde and myeloperoxidase, blood samples were obtained to measure the levels of TNF-alpha and IL-1 beta levels. Histolopatological examination was evaluated with Ki-67, IL-1 beta and VEGF immunostaining densities. RESULTS: There was significant increase in tissue MDA, MPO activity, TNF-alpha and IL-1 beta after ozone administration. There was also a significant difference at immunostaining densities of histopathological examination. CONCLUSIONS: Medical ozone treatment ameliorated the experimental acute distal colitis induced by acetic acid in rats. Its possible effect is by means of decreasing inflammation, edema, and affecting the proliferation and the vascularization.en_US
dc.identifier.doi10.1590/S0102-865020160040000006
dc.identifier.endpage263en_US
dc.identifier.issn0102-8650
dc.identifier.issn1678-2674
dc.identifier.issue4en_US
dc.identifier.pmid27168538en_US
dc.identifier.scopus2-s2.0-84966666538en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage256en_US
dc.identifier.urihttps://doi.org/10.1590/S0102-865020160040000006
dc.identifier.urihttps://hdl.handle.net/11616/97316
dc.identifier.volume31en_US
dc.identifier.wosWOS:000376392600006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherActa Cirurgica Brasileiraen_US
dc.relation.ispartofActa Cirurgica Brasileiraen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectOzoneen_US
dc.subjectAcetic Aciden_US
dc.subjectColitisen_US
dc.subjectRatsen_US
dc.titleMedical ozone treatment ameliorates the acute distal colitis in ratsen_US
dc.typeArticleen_US

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