Synthesis and antimicrobial activity of substituted benzimidazole, benzothiazole and imidazole derivatives

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dc.authoridKUCUKBAY, HASAN/0000-0002-7180-9486
dc.authoridDURMAZ, RIZA/0000-0001-6561-778X
dc.authorwosidKUCUKBAY, HASAN/A-5050-2019
dc.authorwosidDURMAZ, Rıza/HJH-4918-2023
dc.contributor.authorKucukbay, H
dc.contributor.authorCetinkaya, E
dc.contributor.authorDurmaz, R
dc.date.accessioned2024-08-04T20:11:50Z
dc.date.available2024-08-04T20:11:50Z
dc.date.issued1995
dc.departmentİnönü Üniversitesien_US
dc.description.abstractNew benzimidazole, benzothiazole and imidazole derivatives were synthesized by reacting electron-rich olefins (5, 23 and 29) with appropriate reagents The compounds synthesized were identified by H-1, C-13-NMR, FT-IR and mass spectroscopic techniques and micro analysis. All new and related compounds were evaluated for their in vitro antimicrobial activity against different bacteria. The compounds 17, 18, 19, 20, 21, 22 and 24 were found very effective to inhibit the growth of Enterococcus faecalis (ATCC 29212) and Staphylococcus aureus (ATCC 29213) at minimum inhibitory concentrations (MICs) of 25, 25, 12.5, 50, 25, 50 and 50 mu g/ml, respectively. The compounds 4, 10a, 10c, 16, 25, 26 and 31 were significantly effective against Enterococcus faecalis (ATCC 29212) and Staphylococcus aureus (ATCC 29213) with MIC values of 100-200 mu g/ml. None of the compounds proved to be effective against Escherichia coli (ATCC 25922) and Pseudomonas aeruginosa (ATCC 27853) in the concentrations studied.en_US
dc.identifier.endpage1334en_US
dc.identifier.issn0004-4172
dc.identifier.issue12en_US
dc.identifier.pmid8595095en_US
dc.identifier.scopus2-s2.0-0029565762en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage1331en_US
dc.identifier.urihttps://hdl.handle.net/11616/93021
dc.identifier.volume45-2en_US
dc.identifier.wosWOS:A1995TN02000018en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherEcv-Editio Cantor Verlag Medizin Naturwissenschaftenen_US
dc.relation.ispartofArzneimittel-Forschung/Drug Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectantibacterialsen_US
dc.subjectbenzimidazole derivativesen_US
dc.subjectbenzothiazole derivativesen_US
dc.subjectimidazole derivativesen_US
dc.titleSynthesis and antimicrobial activity of substituted benzimidazole, benzothiazole and imidazole derivativesen_US
dc.typeArticleen_US

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