Biochemical changes induced by grape seed extract and low level laser therapy administration during intraoral wound healing in rat liver: an experimental and in silico study

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dc.authoridDemirkol, Mehmet/0000-0003-1973-0364
dc.authoridErdemli, Erman/0000-0003-4596-7525
dc.authoridSelamoglu, Zeliha/0000-0001-9056-6435
dc.authoridDurdagi, Serdar/0000-0002-0426-0905
dc.authoridEkhteiari Salmas, Ramin/0000-0003-3888-5070
dc.authorwosidDemirkol, Mehmet/AAG-8127-2020
dc.authorwosidDurdagi, Serdar/B-6862-2009
dc.authorwosidAKGÜL, Hasan HA/C-6510-2016
dc.authorwosidaksungur, zeynep/AAW-2041-2021
dc.authorwosidErdemli, Erman/ABI-8193-2020
dc.authorwosidDurdagi, Serdar/J-1904-2018
dc.authorwosidEkhteiari Salmas, Ramin/J-6401-2016
dc.contributor.authorErdemli, Mehmet Erman
dc.contributor.authorSalmas, Ramin Ekhteiari
dc.contributor.authorDurdagi, Serdar
dc.contributor.authorAkgul, Hasan
dc.contributor.authorDemirkol, Mehmet
dc.contributor.authorAksungur, Zeynep
dc.contributor.authorSelamoglu, Zeliha
dc.date.accessioned2024-08-04T20:43:05Z
dc.date.available2024-08-04T20:43:05Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn the present study, the changes that occur in rat liver tissue as a result of the use of grape seed extract (GSE) and low level laser therapy (LLLT) in intraoral wound (IW) healing are analyzed using biochemical parameters. Diode laser application groups received 8J/cm(2) dose LLLT once a day for 4days (810nm wavelength, continuous mode, 0.25W, 9s). As a result of the biological parameter analysis, it was determined that the oxidative damage caused by the IWs and recovery period on 7th and 14th days could be substantially removed with GSE applications that have antioxidant capacity especially in rat liver tissue. In addition, the active compound of grape seed, catechin is studied in the active site of glycogen synthase kinase 3 (GSK3) target using molecular modeling approaches. Post-processing molecular dynamics (MD) results for catechin is compared with a standard GSK3 inhibitor. MD simulations assisted for better understanding of inhibition mechanism and the crucial amino acids contributing in the ligand binding. These results along with a through free energy analysis of ligands using sophisticated simulations methods are quite striking and it suggests a greater future role for simulation in deciphering complex patterns of molecular mechanism in combination with methods for understanding drug-receptor interactions.en_US
dc.identifier.doi10.1080/07391102.2017.1305297
dc.identifier.endpage1008en_US
dc.identifier.issn0739-1102
dc.identifier.issn1538-0254
dc.identifier.issue4en_US
dc.identifier.pmid28279122en_US
dc.identifier.scopus2-s2.0-85017147653en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage993en_US
dc.identifier.urihttps://doi.org/10.1080/07391102.2017.1305297
dc.identifier.urihttps://hdl.handle.net/11616/97777
dc.identifier.volume36en_US
dc.identifier.wosWOS:000427724300014en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofJournal of Biomolecular Structure & Dynamicsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLow level laser therapyen_US
dc.subjectintraoral wound healingen_US
dc.subjectoxidative stressen_US
dc.subjectgrape seed extracten_US
dc.subjectliveren_US
dc.subjectraten_US
dc.subjectmolecular modelingen_US
dc.subjectmolecular dockingen_US
dc.subjectinduced fit dockingen_US
dc.subjectMM-PBSAen_US
dc.subjectmolecular dynamics (MD) simulationsen_US
dc.titleBiochemical changes induced by grape seed extract and low level laser therapy administration during intraoral wound healing in rat liver: an experimental and in silico studyen_US
dc.typeArticleen_US

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