Schiff bases and their amines: Synthesis and discovery of carbonic anhydrase and acetylcholinesterase enzymes inhibitors

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dc.authoridGulcin, ilhami/0000-0001-5993-1668
dc.authoridTaslimi, Parham/0000-0002-3171-0633
dc.authorwosidTaslimi, Parham/AAL-2788-2020
dc.authorwosidGök, Yetkin/AAA-5669-2021
dc.authorwosidGulcin, ilhami/F-1428-2014
dc.contributor.authorYigit, Beyhan
dc.contributor.authorYigit, Murat
dc.contributor.authorTaslimi, Parham
dc.contributor.authorGok, Yetkin
dc.contributor.authorGulcin, Ilhami
dc.date.accessioned2024-08-04T20:45:21Z
dc.date.available2024-08-04T20:45:21Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThree series of symmetrical Schiff bases were synthesized from 1,2-diaminoethane, 1,3-diaminopropane and 1,4-diaminobutane and substituted benzaldehydes, and reduced by sodium borohydride to the corresponding benzylic diamines 4-6. All of the compounds obtained were characterized using elemental analysis, FT-IR, H-1 NMR, and C-13 NMR spectroscopy. The enzyme inhibitory properties of these compounds were tested and the influence of the alkane chain length and the substituents on the phenyl group on the enzyme inhibition activity were examined. The novel Schiff bases and their amine derivatives (1a-d, 2a-d, 3b-d, 4a-c, 5a-c, 6a, 6c, 6d) were effective inhibitors of the cytosolic carbonic anhydrase I and II isoforms (hCA I and II), and acetylcholinesterase (AChE) with K-i values in the range of 159.43 +/- 30.03 to 563.73 +/- 115.30nM for hCA I, 104.88 +/- 18.44 to 524.32 +/- 95.03nM for hCA II, and 3.95 +/- 0.74 to 30.83 +/- 6.81nM for AChE.en_US
dc.identifier.doi10.1002/ardp.201800146
dc.identifier.issn0365-6233
dc.identifier.issn1521-4184
dc.identifier.issue9en_US
dc.identifier.pmid30033646en_US
dc.identifier.scopus2-s2.0-85050488789en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1002/ardp.201800146
dc.identifier.urihttps://hdl.handle.net/11616/98398
dc.identifier.volume351en_US
dc.identifier.wosWOS:000443379600003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWiley-V C H Verlag Gmbhen_US
dc.relation.ispartofArchiv Der Pharmazieen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject1,2-diaminoethaneen_US
dc.subject1,3-diaminopropaneen_US
dc.subjectacetylcholinesteraseen_US
dc.subjectcarbonic anhydraseen_US
dc.subjectenzyme inhibitionen_US
dc.subjectSchiff basesen_US
dc.titleSchiff bases and their amines: Synthesis and discovery of carbonic anhydrase and acetylcholinesterase enzymes inhibitorsen_US
dc.typeArticleen_US

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