Synthesis, characterization and biological screening of N-heterocyclic carbene Ag(I) catalysts for aldehyde–amine–alkyne coupling reaction

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dc.contributor.authorBoubakri, Lamia
dc.contributor.authorMnasri, Aziza
dc.contributor.authorSalah, Donia Ben
dc.contributor.authorMansour, Lamjed
dc.contributor.authorGürbüz, Nevin
dc.contributor.authorÖzdemir, İsmail
dc.contributor.authorSauthier, Mathieu
dc.date.accessioned2026-04-04T13:19:01Z
dc.date.available2026-04-04T13:19:01Z
dc.date.issued2025
dc.departmentİnönü Üniversitesi
dc.description.abstractN-heterocyclic carbenes (NHCs) are widely recognized for their applications in organometallic chemistry, catalysis, and pharmaceutical research due to their unique steric and electronic properties. In this study, we report the synthesis of six novel unsymmetrical N,N-disubstituted benzimidazolium salts (2a–f) and their corresponding silver-NHC complexes (3a–f). The structures of all compounds were characterized using nuclear magnetic resonance (NMR), Fourier-transform infrared spectroscopy (FT-IR), and elemental analysis. The biological potential of these compounds was evaluated through in vitro antimicrobial assays against Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Candida albicans, and Candida glabrata. Additionally, anticancer activity was tested against A549, HCT116, and BEAS-2B cell lines, revealing promising results for some derivatives. Preliminary catalytic studies demonstrated the effectiveness of the silver-NHC complexes in A3-coupling reactions involving aldehydes, alkynes, and amines. These reactions yielded propargylamines with high conversion rates (up to 90%) using minimal catalyst amounts. This work highlights the dual utility of these compounds as both potent biological agents and efficient catalysts, paving the way for further exploration of their applications in medicinal chemistry and sustainable catalysis. © 2025 Cellular and Molecular Biology Association. All rights reserved.
dc.description.sponsorshipKing Saud University, KSU
dc.identifier.doi10.14715/cmb/2025.71.5.16
dc.identifier.endpage127
dc.identifier.issn0145-5680
dc.identifier.issue5
dc.identifier.pmid40418553
dc.identifier.scopus2-s2.0-105006667745
dc.identifier.scopusqualityQ4
dc.identifier.startpage118
dc.identifier.urihttps://doi.org/10.14715/cmb/2025.71.5.16
dc.identifier.urihttps://hdl.handle.net/11616/108091
dc.identifier.volume71
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherCellular and Molecular Biology Association
dc.relation.ispartofCellular and Molecular Biology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_Scopus_20250329
dc.subjectantioxidant
dc.subjectbenzimidazolium salts
dc.subjectCatalysis, Structure analysis, N-heterocyclic carbene
dc.subjectenzyme inhibition
dc.subjectsilver(I)-NHC com­plexes
dc.titleSynthesis, characterization and biological screening of N-heterocyclic carbene Ag(I) catalysts for aldehyde–amine–alkyne coupling reaction
dc.typeArticle

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