Assessment of plasma microRNA potentials as a non-invasive biomarker in patients with axial spondyloarthropathy

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dc.authoridYESILADA, ERDEM/0000-0002-1348-6033
dc.authoridAPAYDIN, HAKAN/0000-0001-7219-1457
dc.authorwosidYESILADA, ERDEM/E-4743-2011
dc.contributor.authorYildirim, T.
dc.contributor.authorYesilada, E.
dc.contributor.authorEren, F.
dc.contributor.authorApaydin, H.
dc.contributor.authorGulbay, G.
dc.date.accessioned2024-08-04T20:49:19Z
dc.date.available2024-08-04T20:49:19Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractOBJECTIVE: It is assumed that abnormally expressed MicroRNAs (miRNAs) may be present in the plasma of patients with radiographic axial spondyloarthropathy (rad-AxSpA). Thus, the present study was conducted with the aim of investigating the expression profile of miRNAs in patients with rad-AxSpA. PATIENTS AND METHODS: A total of 15 patients diagnosed with rad-AxSpA according to the Assessment of the SpondyloArthritis International Society (ASAS) classification criteria and nine healthy controls matched for age and gender were included in the study. Demographic data was collected, and disease activity was evaluated using the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI). Peripheral blood samples were collected, and miRNAs were extracted. The expression of microRNAs was analyzed using quantitative Real Time-Polymerase Chain Reaction (qRT-PCR) by the miScript miRNA PCR Array Human Inflammatory Response and Autoimmunity. RESULTS: A total of 84 miRNA profiles were evaluated, and expressions in the study and control groups were compared. When compared to the control group, 6 miRNAs (miR-125b-5p, miR-144-3p, miR-19a-3p, miR-20a-5p, miR-29c-3p, miR-30b-5p) were detected to be upregulated, and 42 miRNAs were detected to be downregulated in the rad-AxSpA group. A p-value < 0.05 was accepted as statistically significant. A significant association was found between miR-145-5p and BASDAI (p = 0.04941). MiR-144-3p, miR-302b-3p, miR-381-3p, miR-497-5p, miR-511-5p, and miR-9-5p were found to be significantly upregulated in the HLA-B27+ patients (p = 0.03063). CONCLUSIONS: Abnormal miRNA expressions were detected in the plasma of the patients with rad-AxSpA. It was concluded that comprehensive studies should be continued to define these miRNAs as diagnostic biomarkers for rad-AxSpA in order to detect its association with Ankylosing Spondylitis disease activity.en_US
dc.identifier.doi10.26355/eurrev_202101_24620
dc.identifier.endpage625en_US
dc.identifier.issn1128-3602
dc.identifier.issue2en_US
dc.identifier.pmid33577015en_US
dc.identifier.scopus2-s2.0-85101396974en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage620en_US
dc.identifier.urihttps://doi.org/10.26355/eurrev_202101_24620
dc.identifier.urihttps://hdl.handle.net/11616/99781
dc.identifier.volume25en_US
dc.identifier.wosWOS:000617204500016en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherVerduci Publisheren_US
dc.relation.ispartofEuropean Review For Medical and Pharmacological Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAxial spondyloarthropathyen_US
dc.subjectMiRNAen_US
dc.subjectBiomarkeren_US
dc.titleAssessment of plasma microRNA potentials as a non-invasive biomarker in patients with axial spondyloarthropathyen_US
dc.typeArticleen_US

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