The relationship of serum asprosin level with diabetic and non-diabetic retinopathy

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dc.authorwosidgürsu, mehmet/HJZ-1663-2023
dc.contributor.authorAtli, H.
dc.contributor.authorOnalan, E.
dc.contributor.authorYakar, B.
dc.contributor.authorKaymaz, T.
dc.contributor.authorDuzenci, D.
dc.contributor.authorKarakulak, K.
dc.contributor.authorDonder, E.
dc.date.accessioned2024-08-04T20:51:50Z
dc.date.available2024-08-04T20:51:50Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractOBJECTIVE: This study was aimed at investigating the role of serum asprosin level in diabetic retinopathy pathogenesis and differential diagnosis diabetic and non-diabetic retinopathy. PATIENTS AND METHODS: The cross-sectional study was conducted between May 2021 and August 2021. A total of 21 subjects with diabetic retinopathy. 21 subjects with non-diabetic retinopathy. 21 subjects with type 2 diabetes mellitus (T2DM) without retinopathy and 21 healthy controls were included in the study. Biochemical parameters, serum asprosin, serum IL-6 and TNF-alpha levels were measured in all participants. RESULTS: Fasting blood glucose (FBG), HbA1c, HOMA-IR and LDL levels were higher in diabetic patients than non-diabetic. The blood asprosin levels were higher in the diabetic retinopathy group compared to the healthy control group (p=0.001). T2DM without diabetic retinopathy (p=0.010), and non-diabetic retinopathy group (p=0.043). There is a significant positive relationship between asprosin level and high FBG, HbA1c and HOMA-IR scores. CONCLUSIONS: Serum asprosin level is significantly increased in DRP group than others. A high asprosin level might be a risk factor for the development of diabetic complications, such as diabetic retinopathy. These findings suggest that the measurement of serum asprosin level may support clinicians in determining the risk of DRP development.en_US
dc.identifier.endpage2123en_US
dc.identifier.issn1128-3602
dc.identifier.issue6en_US
dc.identifier.pmid35363361en_US
dc.identifier.scopus2-s2.0-85127447796en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage2117en_US
dc.identifier.urihttps://hdl.handle.net/11616/100584
dc.identifier.volume26en_US
dc.identifier.wosWOS:000779378300011en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherVerduci Publisheren_US
dc.relation.ispartofEuropean Review For Medical and Pharmacological Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDiabetic retinopathyen_US
dc.subjectNondiabetic retinopathyen_US
dc.subjectAsprosinen_US
dc.titleThe relationship of serum asprosin level with diabetic and non-diabetic retinopathyen_US
dc.typeArticleen_US

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