Prognostic factors of patients who received chemotherapy after cranial irradiation for non-small cell lung cancer with brain metastases: A retrospective analysis of multicenter study (Anatolian Society of Medical Oncology)

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dc.authoridCihan, Şener/0000-0002-3594-3661
dc.authoridOdabas, Hatice/0000-0002-5757-4705
dc.authoridUysal, Mukremin/0000-0002-8524-0665
dc.authoridinal, ali/0000-0002-0690-2529
dc.authoridHacıbekiroğlu, İlhan/0000-0002-0333-7405
dc.authoridduran, Ayse Ocak/0000-0002-1703-726X
dc.authoridOzturk, Banu/0000-0003-0290-8787
dc.authorwosidCihan, Şener/AAW-1956-2021
dc.authorwosidAYDIN, Kubra/ABG-5437-2022
dc.authorwosidGeredeli, Caglayan/AAN-4122-2020
dc.authorwosidOdabas, Hatice/HOH-1716-2023
dc.authorwosidUysal, Mukremin/B-8956-2014
dc.authorwosidinal, ali/J-8056-2012
dc.authorwosidHacıbekiroğlu, İlhan/JCN-7264-2023
dc.contributor.authorInal, Ali
dc.contributor.authorKodaz, Hilmi
dc.contributor.authorOdabas, Hatice
dc.contributor.authorDuran, Ayse Ocak
dc.contributor.authorSeker, Mehmet Metin
dc.contributor.authorInanc, Mevlide
dc.contributor.authorElkiran, Emin Tamer
dc.date.accessioned2024-08-04T20:44:35Z
dc.date.available2024-08-04T20:44:35Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPurpose: Almost half of all patients diagnosed with non-small cell lung cancer (NSCLC) have distant metastases at presentation. One-third of patients with NSCLC will have brain metastases. Without effective treatment, the median survival is only 1 month. However, it is difficult to treat brain metastases with systemic chemotherapy since the agents have difficulty crossing the blood-brain barrier. Therefore, it is important to estimate the patient's survival prognosis. The aim of this study was to analyze prognostic factors for survival in Turkish patients who received chemotherapy after cranial irradiation for NSCLC with brain metastases. Methods: We retrospectively reviewed 698 patients with brain metastases resulting from NSCLC. Ten potential prognostic variables were chosen for analysis. Univariate and multivariate analyses were conducted to identify prognostic factors associated with overall survival (OS). Results: Among the 10 variables for univariate analysis, six were identified to have prognostic significance; these included sex, smoking history, histology, number of brain metastases, extracranial metastases, and neurosurgical resection. Multivariate analysis by the Cox proportional hazard model showed that a smoking history, extracranial metastases, and neurosurgical resection were independent negative prognostic factors for OS. Conclusion: Smoking history, extracranial metastases, and neurosurgical resection were considered independent negative prognostic factors for OS. These findings may facilitate pretreatment prediction of survival and can be used for selecting patients for more appropriate treatment options.en_US
dc.identifier.doi10.4103/0973-1482.176417
dc.identifier.endpage582en_US
dc.identifier.issn0973-1482
dc.identifier.issn1998-4138
dc.identifier.issue3en_US
dc.identifier.pmid29893321en_US
dc.identifier.scopus2-s2.0-85048665590en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage578en_US
dc.identifier.urihttps://doi.org/10.4103/0973-1482.176417
dc.identifier.urihttps://hdl.handle.net/11616/98343
dc.identifier.volume14en_US
dc.identifier.wosWOS:000435353000019en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMedknow Publications & Media Pvt Ltden_US
dc.relation.ispartofJournal of Cancer Research and Therapeuticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBrain metastasesen_US
dc.subjectnon-small cell lung canceren_US
dc.subjectprognostic factorsen_US
dc.titlePrognostic factors of patients who received chemotherapy after cranial irradiation for non-small cell lung cancer with brain metastases: A retrospective analysis of multicenter study (Anatolian Society of Medical Oncology)en_US
dc.typeArticleen_US

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