Effects of apelin on reproductive functions: relationship with feeding behavior and energy metabolism

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dc.authoridYilmaz, Bayram/0000-0002-2674-6535
dc.authoridözyalın, fatma/0000-0001-6486-6389
dc.authoridÖzyalın, Fatma/0000-0001-6486-6389
dc.authoridTekin, Suat/0000-0002-2757-1802
dc.authoridSandal, Suleyman/0000-0002-8916-3329
dc.authoridErden, Yavuz/0000-0002-2807-6096
dc.authorwosidYilmaz, Bayram/IXD-3395-2023
dc.authorwosidözyalın, fatma/ABA-5258-2020
dc.authorwosidTekin, Suat/AAG-1440-2021
dc.authorwosidTekin, Suat/IZD-9868-2023
dc.authorwosidÖzyalın, Fatma/ABC-7193-2020
dc.authorwosidErden, Yavuz/IZE-2291-2023
dc.authorwosidTekin, Suat/KEI-2266-2024
dc.contributor.authorTekin, Suat
dc.contributor.authorErden, Yavuz
dc.contributor.authorSandal, Suleyman
dc.contributor.authorOnalan, Ebru Etem
dc.contributor.authorOzyalin, Fatma
dc.contributor.authorOzen, Hasan
dc.contributor.authorYilmaz, Bayram
dc.date.accessioned2024-08-04T20:42:35Z
dc.date.available2024-08-04T20:42:35Z
dc.date.issued2017
dc.departmentİnönü Üniversitesien_US
dc.description.abstractApelin is an adipose tissue derived peptidergic hormone. In this study, 40 male Sprague-Dawley rats were used (four groups; n=10). Apelin-13 at three different dosages (1, 5 and 50g/kg) was given intraperitoneally while the control group received vehicle the same route for a period of 14 days. In results, apelin-13 caused significant decreases in serum testosterone, luteinizing hormone and follicle-stimulating hormone levels (p<0.05). Administration of apelin-13 significantly increased body weights, food intake, serum low-density lipoprotein and total cholesterol levels (p<0.05), but caused significant decreases in high-density lipoprotein levels (p<0.05). Serum glucose and triglyceride levels were not significantly altered by apelin-13 administration. Significant decreases in both uncoupling protein (UCP)-1 levels in the white and brown adipose tissues and UCP-3 levels in the biceps muscle (p<0.05) were noted. The findings of the study suggest that apelin-13 may not only lead to obesity by increasing body weight but also cause infertility by suppressing reproductive hormones.en_US
dc.description.sponsorshipInonu University Scientific Research Projects Fund [2013/207]en_US
dc.description.sponsorshipThe authors report no declarations of interest. This study was supported by Inonu University Scientific Research Projects Fund (Project # 2013/207).en_US
dc.identifier.doi10.1080/13813455.2016.1211709
dc.identifier.endpage15en_US
dc.identifier.issn1381-3455
dc.identifier.issn1744-4160
dc.identifier.issue1en_US
dc.identifier.pmid27494693en_US
dc.identifier.scopus2-s2.0-84982831992en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage9en_US
dc.identifier.urihttps://doi.org/10.1080/13813455.2016.1211709
dc.identifier.urihttps://hdl.handle.net/11616/97470
dc.identifier.volume123en_US
dc.identifier.wosWOS:000394686200002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofArchives of Physiology and Biochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectApelinen_US
dc.subjectreproductive functionsen_US
dc.subjectfood intakeen_US
dc.subjectbody weighten_US
dc.subjectuncoupling proteinsen_US
dc.titleEffects of apelin on reproductive functions: relationship with feeding behavior and energy metabolismen_US
dc.typeArticleen_US

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