Synthesis a group of 5(6)-substituted benzimidazole Zn(II) and Co(II) complexes and investigation their cytotoxic and antimicrobial activities

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dc.authoridYılmaz, Ülkü/0000-0002-2806-4781
dc.authoridYesilada, Ozfer/0000-0003-0038-6575
dc.authoridYilmaz, Omer/0000-0002-0962-2725
dc.authoridYilmaz, Ozgur/0000-0001-6489-761X
dc.authorwosidYılmaz, Ülkü/AAA-7545-2020
dc.authorwosidYesilada, Ozfer/ABI-1335-2020
dc.authorwosidYilmaz, Omer/KHZ-8294-2024
dc.contributor.authorYilmaz, Ulku
dc.contributor.authorApohan, Elif
dc.contributor.authorKucukbay, Hasan
dc.contributor.authorYilmaz, Ozgur
dc.contributor.authorTatlici, Eray
dc.contributor.authorYesilada, Ozfer
dc.date.accessioned2024-08-04T20:51:41Z
dc.date.available2024-08-04T20:51:41Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractA series of 5(6)-substituted benzimidazole ligand-zinc(II) and cobalt(II) complexes were synthesized and characterized by H-1, C-13 NMR, IR, CHN analysis techniques. In vitro, anticancer and antimicrobial activities of ligand and complexes were evaluated. The cytotoxic activities of compounds were investigated against the human lung adenocarcinoma (A549) cell lines and healthy human lung bronchial epithelium (BEAS2B) cells. Compounds 1, 6, and 8 were observed to exhibit higher cytotoxic activity than the others at the 72nd hour. Also, the compounds showed varying degrees of antimicrobial activity against the microorganisms used. Compounds 1, 5, and 8 were most effective against standard strains Pseudomonas aeruginosa ATCC 27853 and Staphylococcus aureus ATCC 29213. As for the antifungal activity, compounds 1, 5, 6, and 8 showed high antifungal activity against the yeast type fungi Candida albicans ATCC 90028 and Candida tropicalis.en_US
dc.description.sponsorshipInonu Universitesi [2014/33]en_US
dc.description.sponsorshipInonu Universitesi, Grant/Award Number: 2014/33en_US
dc.identifier.doi10.1002/jhet.4463
dc.identifier.endpage1246en_US
dc.identifier.issn0022-152X
dc.identifier.issn1943-5193
dc.identifier.issue7en_US
dc.identifier.scopus2-s2.0-85124735058en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1241en_US
dc.identifier.urihttps://doi.org/10.1002/jhet.4463
dc.identifier.urihttps://hdl.handle.net/11616/100490
dc.identifier.volume59en_US
dc.identifier.wosWOS:000757226100001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Heterocyclic Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTransition-Metal-Complexesen_US
dc.subjectSchiff-Base Liganden_US
dc.subjectStructural-Characterizationen_US
dc.subjectAnticancer Activityen_US
dc.subjectZinc(Ii) Complexesen_US
dc.subjectCatalytic-Activityen_US
dc.subjectCrystal-Structuresen_US
dc.subjectDnaen_US
dc.subjectCanceren_US
dc.subjectDerivativesen_US
dc.titleSynthesis a group of 5(6)-substituted benzimidazole Zn(II) and Co(II) complexes and investigation their cytotoxic and antimicrobial activitiesen_US
dc.typeArticleen_US

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