Progressive Multifocal Leukoencephalopathy after Three Consecutive Liver Transplantations
Küçük Resim Yok
Tarih
2015
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Avicenna Organ Transplant Center
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Progressive multifocal leukoencephalopathy (PML) is a lytic infection of the central nervous system caused by the reactivation of John Cunningham Virus (JCV) in severely immunosuppressed patients. Occurrence of PML after solid organ transplantations, especially after liver transplantation, is rare. If a patient has poor prognostic factors such as atypical radiological involvements or high viral load in cerebrospinal fluid (CSF), overall survival rates could be poor. Herein, we report on a patients who underwent liver transplantation three times and developed PML with unexpected radiological findings; he was also positive for JCV DNA with a high viral load. Although there are limited data about efficacy of cytarabine against JCV, it was given to the patient for five days. Despite the initiation of cytarabine and complete cessation of the immunosuppressive therapy, we lost the patient, unfortunately.
Açıklama
Anahtar Kelimeler
Liver transplantation, Leukoencephalopathy, progressive multifocal, JC virus, Immunocompromised host, Viral load
Kaynak
International Journal of Organ Transplantation Medicine
WoS Q Değeri
N/A
Scopus Q Değeri
Q3
Cilt
6
Sayı
3
