Dosimetric analysis of SIB whole brain radiotherapy planning: Comparison of coplanar VMAT and tomotherapy techniques

Basit Öğe Kaydı
dc.contributor.authorPepele, Eda Kaya
dc.contributor.authorTemelli, Oztun
dc.date.accessioned2026-04-04T13:37:45Z
dc.date.available2026-04-04T13:37:45Z
dc.date.issued2025
dc.departmentİnönü Üniversitesi
dc.description.abstractBackground Radiotherapy techniques have advanced significantly over the past few decades. Whole-brain radiotherapy combined with a simultaneous integrated boost (WBRT+SIB) is increasingly used to treat limited brain metastases. Purpose To retrospectively compare helical tomotherapy and coplanar volumetric modulated arc therapy (VMAT) for WBRT with a SIB-WBRT in patients with multiple brain metastases. Additionally, it emphasizes the importance of selecting appropriate evaluation indices when comparing SIB plans. Materials and methods Fifteen patients with 2- 3 metastatic lesions were retrospectively analyzed in this study. Treatment planning was performed using TomoHD and eclipse planning systems for tomotherapy and VMAT, respectively. Dose-volume histograms were used to assess the doses delivered to the target volumes and organs at risk (OARs). Quantitative metrics, including the homogeneity index (HI), conformity index (CI), and plan quality index (PQI), were used for the evaluation. Results Tomotherapy yielded significantly higher D98% values for both the planning target volume (PTV) WB and PTV_met compared with VMAT (p < 0.05). It also provided lower D-max and D-mean values for the lenses and eyes (p < 0.001 and p < 0.02, respectively). Tomotherapy was superior in terms of PTV whole-brain CI and PTV_met HI and CI (p < 0.05). However, no significant difference was observed in the PQI values between the techniques (p > 0.05). Conclusion Both tomotherapy and VMAT achieved acceptable target volumes and OAR doses in SIB applications. Tomotherapy showed advantages in terms of dose conformity and critical organ sparing. Moreover, this study highlights the impact of selecting appropriate evaluation indices on interpreting plan quality, particularly for complex treatment approaches such as SIB.
dc.identifier.doi10.1002/acm2.70313
dc.identifier.issn1526-9914
dc.identifier.issue11
dc.identifier.pmid41134529
dc.identifier.scopus2-s2.0-105019790765
dc.identifier.scopusqualityN/A
dc.identifier.urihttps://doi.org/10.1002/acm2.70313
dc.identifier.urihttps://hdl.handle.net/11616/110023
dc.identifier.volume26
dc.identifier.wosWOS:001600778100001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of Applied Clinical Medical Physics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250329
dc.subjectbrain metastases
dc.subjectCI
dc.subjectdosimetric analysis HI
dc.subjectPQI
dc.subjecttomotherapy
dc.subjectVMAT
dc.titleDosimetric analysis of SIB whole brain radiotherapy planning: Comparison of coplanar VMAT and tomotherapy techniques
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu