Protective role of melatonin in pinealectomized rat brains: in vivo magnetic resonance spectroscopic analysis

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dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authoridParlakpinar, Hakan/0000-0001-9497-3468
dc.authoridKarakas, Hakki/0000-0002-1328-8520
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.authorwosidParlakpinar, Hakan/V-6637-2019
dc.contributor.authorHascalik, S
dc.contributor.authorCelik, O
dc.contributor.authorKarakas, HM
dc.contributor.authorParlakpinar, H
dc.contributor.authorFirat, AK
dc.contributor.authorOzsahin, M
dc.date.accessioned2024-08-04T20:15:05Z
dc.date.available2024-08-04T20:15:05Z
dc.date.issued2005
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe goal of this study was to investigate the effect of melatonin on basic cerebral metabolites in pinealectomized (Px) rat brains. Twenty-one rats were randomly divided into three groups with seven rats per group. The study groups included sham-operated rats, Px rats and Px rats treated with melatonin. Melatonin administration began at 60 days following pinealectomy and continued for 21 days. At the end of the study, in vivo single voxel magnetic resonance spectroscopy was performed on whole brains to determine choline (Cho), creatine and N-acetyl aspartate (NAA) concentrations. Px rats had significantly lower NAA levels (P < 0.05), and significantly higher Cho levels (P < 0.05) when compared with sham-operated rats. Administration of melatonin had normalized NAA and Cho levels in Px rats. We propose that pinealectomy causes significant changes in cerebral metabolites which are compatible with neural loss. Melatonin administration prevents the disruptive effects of pinealectomy on brain tissue.en_US
dc.identifier.doi10.1111/j.1600-079X.2005.00255.x
dc.identifier.endpage345en_US
dc.identifier.issn0742-3098
dc.identifier.issn1600-079X
dc.identifier.issue4en_US
dc.identifier.pmid16207288en_US
dc.identifier.scopus2-s2.0-27744576958en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage342en_US
dc.identifier.urihttps://doi.org/10.1111/j.1600-079X.2005.00255.x
dc.identifier.urihttps://hdl.handle.net/11616/94166
dc.identifier.volume39en_US
dc.identifier.wosWOS:000232389300002en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Pineal Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectantioxidantsen_US
dc.subjectmagnetic resonance spectroscopyen_US
dc.subjectmelatoninen_US
dc.subjectpinealectomyen_US
dc.subjectrat brainen_US
dc.titleProtective role of melatonin in pinealectomized rat brains: in vivo magnetic resonance spectroscopic analysisen_US
dc.typeArticleen_US

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