The protective effects of apocynin on ionizing radiation-induced intestinal damage in rats

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dc.authoridVardı, Nigar/0000-0003-0576-1696
dc.authoridPolat, Alaadin/0000-0002-6920-3856
dc.authoriderdogan, mehmet ali/0000-0002-1713-5695
dc.authoridParlakpinar, Hakan/0000-0001-9497-3468
dc.authoridYildiz, Azibe/0000-0001-5686-7867
dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authoridCagin, Yasir Furkan/0000-0002-2538-857X
dc.authorwosidSarıhan, Mehmet Ediz/JMQ-5971-2023
dc.authorwosidVardı, Nigar/C-9549-2018
dc.authorwosidPolat, Alaadin/AAA-7171-2021
dc.authorwosiderdogan, mehmet ali/ABI-4675-2020
dc.authorwosidParlakpinar, Hakan/V-6637-2019
dc.authorwosidYildiz, Azibe/ABI-7998-2020
dc.authorwosidEkici, Kemal/AAF-6505-2022
dc.contributor.authorCagin, Y. F.
dc.contributor.authorParlakpinar, H.
dc.contributor.authorPolat, A.
dc.contributor.authorVardi, N.
dc.contributor.authorAtayan, Y.
dc.contributor.authorErdogan, M. A.
dc.contributor.authorEkici, K.
dc.date.accessioned2024-08-04T20:41:41Z
dc.date.available2024-08-04T20:41:41Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground and aims: Radiation colitis typically emerges during radiotherapy of intra-abdominal malignancies. While the underlying mechanism remains unclear, it is considered that free oxygen radicals act like cellular mediators to cause colonic damage. Apocynin (APO) prevents oxidative stress and apoptotic cell death by inhibiting NADPH oxidase, and preventing the formation of free oxygen radicals. The aim of the present study was to investigate the protective effect of APO, a strong antioxidant and antiinflammatory agent, on radiation induced colonic oxidative damage in rats.Materials and methods: Rats were randomly divided into four groups (n=8/group). Group I (control group); Group II (Group RAD) received a single dose of 800 cGy ionizing radiation to the whole abdomen with a linear accelerator (LINAC); Group III (Group APO) received a single dose of 20mg/kg of APO intraperitoneally for five days; Group IV (Group APO+RAD) received APO for five days before radiation exposure (similar to Group III), (similar to Group II).Results: APO treatment prior to radiation led to protection in the biochemical and histopathological parameters.Conclusions: Our study shows that APO treatment before radiation improves radiation induced colonic injury in rats, by decreasing oxidative stress and apoptosis.en_US
dc.identifier.doi10.3109/03639045.2015.1052080
dc.identifier.endpage324en_US
dc.identifier.issn0363-9045
dc.identifier.issn1520-5762
dc.identifier.issue2en_US
dc.identifier.pmid26072994en_US
dc.identifier.scopus2-s2.0-84964294815en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage317en_US
dc.identifier.urihttps://doi.org/10.3109/03639045.2015.1052080
dc.identifier.urihttps://hdl.handle.net/11616/97287
dc.identifier.volume42en_US
dc.identifier.wosWOS:000368025300015en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofDrug Development and Industrial Pharmacyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectApocyninen_US
dc.subjectintestine damageen_US
dc.subjectoxidative stressen_US
dc.subjectradiationen_US
dc.subjectraten_US
dc.titleThe protective effects of apocynin on ionizing radiation-induced intestinal damage in ratsen_US
dc.typeArticleen_US

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