Preparation and characterization of PEPPSI-palladium N-heterocyclic carbene complexes using benzimidazolium salts catalyzed Suzuki-Miyaura cross coupling reaction and their antitumor and antimicrobial activities

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dc.authoridYaşar, Sedat/0000-0001-7285-2761
dc.authoridÖzdemir, İsmail/0000-0001-6325-0216
dc.authorwosidYaşar, Sedat/ABG-8356-2020
dc.authorwosidÖzdemir, İsmail/ABI-5192-2020
dc.contributor.authorBoubakri, Lamia
dc.contributor.authorDridi, Khaireddine
dc.contributor.authorAl-Ayed, Abdullah Sulaiman
dc.contributor.authorOzdemir, Ismail
dc.contributor.authorYasar, Sedat
dc.contributor.authorHamdi, Naceur
dc.date.accessioned2024-08-04T20:45:54Z
dc.date.available2024-08-04T20:45:54Z
dc.date.issued2019
dc.departmentİnönü Üniversitesien_US
dc.description.abstractNew palladium complexes were efficiently synthesized from the reaction of benzimidazolium salts 2a-e, potassium carbonate (K2CO3) and palladium chloride (PdCl2) in pyridine (for 3a-e). The catalytic activity of these complexes in a catalytic system including palladium complexes and K2CO3 in DMF-H2O was evaluated in Suzuki-Miyaura cross-coupling reactions of aryl bromides and chlorides with phenylboronic acid. Our novel complexes show excellent catalytic activities with high turnover numbers (TON) and high turnover frequencies (TOF) (e.g. for the Suzuki-Miyaura reaction: TON up to 370 and TOF up to 123.3 h(-1)). Both benzimidazolium salts 2a-e and complexes 3 have been characterized using spectroscopic data and elemental analysis. The antimicrobial activity of the N-heterocyclic carbene palladium complexes 3a-e varies with the nature of the ligands. Also, the IC50 values of both, complexes (3a-e) and benzimidazoles 2a-e, have been determined. In addition, the new palladium complexes were screened for their antitumor activity. Complexes 3e and 3d exhibited the highest antitumor effect with IC50 values 6.85 mu g/mL against MCF-7 and 10.75 mu g/mL against T47D, respectively. [GRAPHICS] .en_US
dc.identifier.doi10.1080/00958972.2019.1572886
dc.identifier.endpage527en_US
dc.identifier.issn0095-8972
dc.identifier.issn1029-0389
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85065014098en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage516en_US
dc.identifier.urihttps://doi.org/10.1080/00958972.2019.1572886
dc.identifier.urihttps://hdl.handle.net/11616/98773
dc.identifier.volume72en_US
dc.identifier.wosWOS:000466173300010en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofJournal of Coordination Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSuzuki-Miyaura couplingen_US
dc.subjectN-heterocyclic carbeneen_US
dc.subjectpalladium(II) catalysten_US
dc.subjectantimicrobial activityen_US
dc.subjectantitumor activityen_US
dc.titlePreparation and characterization of PEPPSI-palladium N-heterocyclic carbene complexes using benzimidazolium salts catalyzed Suzuki-Miyaura cross coupling reaction and their antitumor and antimicrobial activitiesen_US
dc.typeArticleen_US

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