Therapeutic effects of ivabradine on hemodynamic parameters and cardiotoxicity induced by doxorubicin treatment in rat

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dc.authoridPolat, Alaadin/0000-0002-6920-3856
dc.authoridParlakpinar, Hakan/0000-0001-9497-3468
dc.authoridAcet, Ahmet/0000-0003-1131-1878
dc.authoridKose, Evren/0000-0002-0246-2589
dc.authoridTurkmen, Samdanci, Emine/0000-0002-0034-5186
dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authoridSarihan, Mehmet Ediz/0000-0002-1266-4213
dc.authorwosidPolat, Alaadin/AAA-7171-2021
dc.authorwosidParlakpinar, Hakan/V-6637-2019
dc.authorwosidAcet, Ahmet/AAB-3273-2021
dc.authorwosidColak, M. Cengiz/ABI-3394-2020
dc.authorwosidKose, Evren/ABG-9908-2020
dc.authorwosidTurkmen, Samdanci, Emine/ABH-4716-2020
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.contributor.authorColak, M. C.
dc.contributor.authorParlakpinar, H.
dc.contributor.authorTasdemir, S.
dc.contributor.authorSamdanci, E.
dc.contributor.authorKose, E.
dc.contributor.authorPolat, A.
dc.contributor.authorSarihan, E.
dc.date.accessioned2024-08-04T20:36:10Z
dc.date.available2024-08-04T20:36:10Z
dc.date.issued2012
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe aim of this study was to investigate the possible effects of ivabradine against doxorubicin (DOX)-induced cardiotoxicity in rats using hemodynamic parameters (electrocardiogram, heart rate (HR), and blood pressure), biochemical markers of oxidative stress, lactate dehydrogenase, aspartate transaminase, creatine kinase-MB, and histopathological analyses both in serum and tissue specimens. A total of 28 female rats were randomly assigned to 4 groups: (a) control (n = 6 rats), (b) DOX group (n = 7 rats), (c) DOX + ivabradine-treated group (n = 8 rats), and (d) ivabradine group (n = 7 rats). When the means of the four groups were compared, there was only a significant difference in the level of HR (p < 0.05). DOX treatment caused more HR elevation when compared to the control group, whereas ivabradine application after DOX treatment significantly reduced HR levels. Cardiomyocytes were revealed as normal histology in the light of both hematoxylin and eosin staining and immunostaining methods (caspase-3 and bcl-2) in all groups. The present study reported the therapeutic effects of ivabradine against DOX-induced cardiotoxicity accompanied by the hemodynamic and biochemical parameters.en_US
dc.identifier.doi10.1177/0960327112438288
dc.identifier.endpage954en_US
dc.identifier.issn0960-3271
dc.identifier.issn1477-0903
dc.identifier.issue9en_US
dc.identifier.pmid22354086en_US
dc.identifier.scopus2-s2.0-84866501531en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage945en_US
dc.identifier.urihttps://doi.org/10.1177/0960327112438288
dc.identifier.urihttps://hdl.handle.net/11616/95805
dc.identifier.volume31en_US
dc.identifier.wosWOS:000308881500010en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofHuman & Experimental Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCardiotoxicityen_US
dc.subjectDoxorubucinen_US
dc.subjectHemodynamic Parametersen_US
dc.subjectIvabradineen_US
dc.titleTherapeutic effects of ivabradine on hemodynamic parameters and cardiotoxicity induced by doxorubicin treatment in raten_US
dc.typeArticleen_US

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