Effects of Apocynin on Liver Ischemia-Reperfusion Injury in Rats

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dc.authoridYücel, Aytaç/0000-0003-0270-8339
dc.authoridSARICI, KEMAL BARIŞ/0000-0001-9595-1906
dc.authoridUçar, Muharrem/0000-0002-1232-9829
dc.authoridaydogan, mustafa said/0000-0002-7106-1156
dc.authorwosidYücel, Aytaç/ABI-6137-2020
dc.authorwosidSARICI, KEMAL BARIŞ/ABI-4356-2020
dc.authorwosidUçar, Muharrem/ABH-7761-2020
dc.authorwosidaydogan, mustafa said/AAA-2828-2021
dc.contributor.authorYucel, A.
dc.contributor.authorAydogan, M. S.
dc.contributor.authorUcar, M.
dc.contributor.authorSarici, K. B.
dc.contributor.authorKaraaslan, M. G.
dc.date.accessioned2024-08-04T20:45:55Z
dc.date.available2024-08-04T20:45:55Z
dc.date.issued2019
dc.departmentİnönü Üniversitesien_US
dc.description12th Congress of the Turkish-Transplantation-Centers-Coordination-Association (TTCCA) -- OCT 18-21, 2018 -- Trabzon, TURKEYen_US
dc.description.abstractObjective. Ischemia-reperfusion (IR) injury is associated with various clinical conditions, such as myocardial infarction, shock, and surgery under vascular occlusion. We aimed to investigate the protective and therapeutic effects of apocynin (AP) on liver injury induced by IR in an in vivo rat model. Methods. Thirty-two rats were randomly divided into 4 experimental groups with n = 8 in each group: sham, IR, AP, and IR + AP. AP (20 mg/kg) was intraperitoneally administered to rats in the AP and IR + AP groups for 30 minutes before 60 minutes of ischemia and followed by 60 minutes of reperfusion. All rats were killed on the same day to evaluate tissue levels of oxidants and antioxidants (catalase, malondialdehyde, myeloperoxidase, superoxidedismutase (SOD), and total glutathione). Results. IR decreased SOD levels in IR group when compared with the sham group. AP supplementation to IR group significantly ameliorated SOD levels (P < .05). Also, IR caused elevation of myeloperoxidase production when compared with the sham group, whereas AP treatment prevented these hazardous effects (P < .05). However, plasma total glutathione, catalase, and malondialdehyde levels did not differ between the AP + IR and the IR rats. Conclusion. The main finding of the present study was that AP may be protective against liver IR injury. Our results suggested that AP pretreatment suppressed oxidative stress and increased antioxidant levels in an rat model of liver IR.en_US
dc.description.sponsorshipTurkish Transplantat Ctr Coordinat Assocen_US
dc.identifier.doi10.1016/j.transproceed.2019.01.108
dc.identifier.endpage1183en_US
dc.identifier.issn0041-1345
dc.identifier.issn1873-2623
dc.identifier.issue4en_US
dc.identifier.pmid31101195en_US
dc.identifier.scopus2-s2.0-85065506294en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1180en_US
dc.identifier.urihttps://doi.org/10.1016/j.transproceed.2019.01.108
dc.identifier.urihttps://hdl.handle.net/11616/98785
dc.identifier.volume51en_US
dc.identifier.wosWOS:000500179300037en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofTransplantation Proceedingsen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectInflammationen_US
dc.subjectActivationen_US
dc.subjectGlucanen_US
dc.titleEffects of Apocynin on Liver Ischemia-Reperfusion Injury in Ratsen_US
dc.typeConference Objecten_US

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