Swiss Albino Farelerde Alkol ve Sigaranin Testis Dokusu Üzerine Etkileri
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Dosyalar
Tarih
2004
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
İnönü Üniversitesi Tıp Fakültesi Dergisi
Erişim Hakkı
Attribution 3.0 United States
Özet
Sunulan araştırma, erişkin erkek Swiss albino farelerde uzun süreli alkol, pasif sigara, alkol+pasif sigara kombinasyonunun testis dokusuna etkilerini ortaya koymak amacıyla yapılmıştır.
Gereç ve Yöntem: Çalışmada 32 adet erişkin erkek Swiss albino fare kullanıldı. Fareler dört eşit gruba ayrıldı (n1=...n4=8). Kontrol grubuna herhangi bir işlem uygulanmazken deney gruplarındaki hayvanlar altı hafta boyunca alkol, pasif sigara ve alkol+pasif sigaraya maruz bırakıldı.
Bulgular: Gruplar arasında total veya nisbi testis ağırlıklarında fark gözlenmedi. Ortalama seminifer tübül çaplarının kontrol grubu ile karşılaştırıldığında pasif sigara, alkol ve alkol+pasif sigara gruplarında giderek azaldığı görüldü. Bu azalma kontrol ile alkol grupları arasında (p=0,02); kontrol ile alkol+pasif sigara grupları arasında (p=0,006); alkol ile pasif sigara grupları arasında (p=0,005); pasif sigara ile alkol+pasif sigara grupları arasında (p=0,004) istatistiksel olarak anlamlı bulundu. Kesitler mikroskopik olarak incelendiğinde pasif sigara ve alkol grubundaki bazı kesitlerde
seminifer tübül epitelinde yer yer dejenerasyon ve Leydig hücrelerinde artma gözlendi. Alkol+pasif sigara grubunda seminifer tübül duvarındaki dejeneratif değişikliklerin daha fazla olduğu gözlendi.
Sonuç: Sunulan araştırmada alkol, pasif sigara ve alkol+pasif sigara uygulamasının farelerin testis dokusunda hasara neden olduğu ve alkol+pasif sigara uygulaması yapılan grupta bu değişikliklerin daha belirgin olduğu tespit edildi.
The aim of this study, was to investigate the effects of alcohol, passive smoking and alcohol+passive smoking on the testicular morphology of the adult Swiss albino mice. Method: 32 male Swiss albino mice were used in this study. The animals were divided randomly in to four groups (n1=...n4=8): one group served as the control group, and the others were subjected to either alcohol, passive smoking or alcohol + passive smoking for 6 weeks. Results: No differences were found in absolute or relative testis weights among the different groups. The mean seminiferous tubule diameter was gradually decreased in passive smoking, alcohol and alcohol + passive smoking groups when compared with control group. We found a statistically significant difference between control and alcohol + passive smoking groups (p=0,006), alcohol and passive smoking groups (p=0,005), and passive smoking and alcohol + passive smoking groups (p=0,004). Seminiferous tubules containing degenerated germinal epithelium and decrease in number of Leydig cells were observed in a few tubules of testes from passive smoking and alcohol groups. Degenerative changes were more severe in the group exposed to both alcohol and cigarette smoke. Conclusion: In the present study, it was observed that alcohol, passive smoking and alcohol + passive smoking caused injury in testis tissue of Swiss albino mice and that these changes were more severe in alcohol + passive smoking group.
The aim of this study, was to investigate the effects of alcohol, passive smoking and alcohol+passive smoking on the testicular morphology of the adult Swiss albino mice. Method: 32 male Swiss albino mice were used in this study. The animals were divided randomly in to four groups (n1=...n4=8): one group served as the control group, and the others were subjected to either alcohol, passive smoking or alcohol + passive smoking for 6 weeks. Results: No differences were found in absolute or relative testis weights among the different groups. The mean seminiferous tubule diameter was gradually decreased in passive smoking, alcohol and alcohol + passive smoking groups when compared with control group. We found a statistically significant difference between control and alcohol + passive smoking groups (p=0,006), alcohol and passive smoking groups (p=0,005), and passive smoking and alcohol + passive smoking groups (p=0,004). Seminiferous tubules containing degenerated germinal epithelium and decrease in number of Leydig cells were observed in a few tubules of testes from passive smoking and alcohol groups. Degenerative changes were more severe in the group exposed to both alcohol and cigarette smoke. Conclusion: In the present study, it was observed that alcohol, passive smoking and alcohol + passive smoking caused injury in testis tissue of Swiss albino mice and that these changes were more severe in alcohol + passive smoking group.
Açıklama
İnönü Üniversitesi Tıp Fakültesi Dergisi
11(1) 1-6 (2004)
Anahtar Kelimeler
Swiss Albino Fare, Alkol, Sigara, Testis, Swiss Albino Mice, Alcohol, Passive Smoking
Kaynak
WoS Q Değeri
Scopus Q Değeri
Cilt
Sayı
Künye
Erpek, Semra ;Balkaya, Muharrem ;Ünsal, Hümeyra ;Ünsal, Cengiz ;İnönü Üniversitesi Tıp Fakültesi Dergisi 11(1) 1-6 (2004)
