Examination of the effect of melatonin use before hysterosalpingography on ovarian follicle reservein rats

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dc.contributor.authorYilmaz, E. S.
dc.contributor.authorSapmaz, T.
dc.contributor.authorKazgan, H
dc.contributor.authorYildiz, S. Menziletoglu
dc.contributor.authorKocamaz, D
dc.contributor.authorAkpolat, N.
dc.contributor.authorSapmaz, E.
dc.date.accessioned2019-07-11T12:26:52Z
dc.date.available2019-07-11T12:26:52Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: To examine the effects of lipiodol, melatonin, and radiation used during hysterosalpingography (HSG) on rat ovarian follicle reserve. Materials and Methods: A total of 50 Wistar rats with regular estrous cycles were randomly divided into five groups. Group 1 was the control group. The other groups, X-ray was applied (G2), 0.1 ml lipiodol was applied to each uterine horn (G3), 20 mg/kg intraperitoneal melatonin application was followed by 0.1 ml lipiodol administration to each uterine horn after 15 minutes (G4), 20 mg/kg melatonin was administered to ligamentum suspensorium ovarii, followed by 0.1 ml lipiodol application to each uterine horn after 15 minutes (G5), respectively. The rats in G2, G3, G4, and G5 were exposed three times to whole body radiation. Then, all rats were re-opened and left oophorectomy was performed. Left ovarian samples were fixed in formaldehyde. Primordial, primary, secondary, and tertiary follicles were counted in the preparations, and all were added to calculate the ovarian follicle reserve. Results: Primordial, primary, and ovarian follicle reserves were found significantly lower in G2, in comparison to other groups. Atretic follicle values were significantly higher in G2 compared to G3, and in G3 compared to the other groups. Regression of angiogenesis within corpus luteum was found significantly lower in G2, compared to G3, and in G3 compared to other groups. All values in G1, G4, and G5 were similar. Conclusion: Use of lipiodol and melatonin during HSG procedure prevents the negative effects of radiation on ovarian follicle reserve. Keywordsen_US
dc.identifier.citationYilmaz, ES. Sapmaz, T. Kazgan, H. Yildiz, SM. Kocamaz, D. Akpolat, N. Sapmaz, E . (2018). Examination of the effect of melatonin use before hysterosalpingography on ovarian follicle reservein rats. Cilt:45. Sayı:4. 570-574 ss.en_US
dc.identifier.doi10.12891/ceog4236.2018en_US
dc.identifier.endpage574en_US
dc.identifier.issue4en_US
dc.identifier.startpage570en_US
dc.identifier.urihttps://hdl.handle.net/11616/12541
dc.identifier.volume45en_US
dc.language.isoenen_US
dc.publisherI r o g canada, ınc, 4900 cote st-luc, apt#212, montreal, quebec h3w 2h3, canadaen_US
dc.relation.ispartofClınıcal and experımental obstetrıcs & gynecologyen_US
dc.rightsinfo:eu-repo/semantics/restrictedAccessen_US
dc.subjectIschemıa-reperfusıon ınjuryen_US
dc.subjectendothelıal growth-factoren_US
dc.subjectradıonuclıde hysterosalpıngographyen_US
dc.subjectcontrast sonographyen_US
dc.subjectfemale ınfertılıtyen_US
dc.subjectlıpıd-peroxıdatıonen_US
dc.subjectoxıdatıve stressen_US
dc.subjectın-vıtroen_US
dc.subjectexpressıonen_US
dc.subjectpathophysıologyen_US
dc.titleExamination of the effect of melatonin use before hysterosalpingography on ovarian follicle reservein ratsen_US
dc.typeArticleen_US

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