Quercetin prevents docetaxel- induced testicular damage in rats

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dc.authoridAKPOLAT, Nusret/0000-0002-9138-2117
dc.authoridaydin, muhterem/0000-0002-6494-9229
dc.authoridBeytur, Ali/0000-0002-7870-3318
dc.authoridCiftci, Osman/0000-0001-5755-3560
dc.authorwosidAKPOLAT, Nusret/ABF-6986-2020
dc.authorwosidaltintas, ramazan/AAP-2348-2020
dc.authorwosidaydin, muhterem/W-4192-2018
dc.authorwosidBeytur, Ali/AAA-2823-2021
dc.contributor.authorAltintas, R.
dc.contributor.authorCiftci, O.
dc.contributor.authorAydin, M.
dc.contributor.authorAkpolat, N.
dc.contributor.authorOguz, F.
dc.contributor.authorBeytur, A.
dc.date.accessioned2024-08-04T20:40:07Z
dc.date.available2024-08-04T20:40:07Z
dc.date.issued2015
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe protective effect of quercetin on docetaxel - an anticancer agent - induced testicular damage in rats was investigated. Thirty-two rats were randomly divided into four groups: group 1 - control, carrier solutions were given; group 2 - quarcetin 20mgkg(-1)day(-1) was given orally; group 3 - docetaxel 5mgkg(-1) was given intraperitoneally as single dose; group 4 - docetaxel and quarcetin were given together. The histopathological changes; the specific biochemical markers, including antioxidants; and the sperm characteristics were evaluated. Docetaxel caused a significant increase in TBARS level and a significant decrease in SOD, GPX, CAT and GSH levels in the testicular tissues compared with the control group, whereas quercetin led to a significant decrease in lipid peroxidation, which was caused by docetaxel, via reducing TBARS level and increasing the levels of SOD, CAT, GPX and GSH. In addition, after docetaxel administration, sperm motility, sperm concentration, testicular and epididymis weights were significantly decreased and abnormal sperm rate and histopathological changes were increased. However, these effects of docetaxel on sperm parameters, histological changes and the tissue weights were eliminated by quercetin treatment. Our results show that the administration of docetaxel induced the testicular damage (oxidative stress, testes tissue damage and sperm parameters), and quercetin prevented docetaxel-induced testicular damage in rats.en_US
dc.description.sponsorshipInonu University, Scientific Research Projects Coordination Unit [2011/195]en_US
dc.description.sponsorshipThis study has been supported by Inonu University, Scientific Research Projects Coordination Unit (Project No: 2011/195).en_US
dc.identifier.doi10.1111/and.12253
dc.identifier.endpage256en_US
dc.identifier.issn0303-4569
dc.identifier.issn1439-0272
dc.identifier.issue3en_US
dc.identifier.pmid24601972en_US
dc.identifier.scopus2-s2.0-84923636571en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage248en_US
dc.identifier.urihttps://doi.org/10.1111/and.12253
dc.identifier.urihttps://hdl.handle.net/11616/96696
dc.identifier.volume47en_US
dc.identifier.wosWOS:000350490000003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofAndrologiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDocetaxelen_US
dc.subjectquercetinen_US
dc.subjectraten_US
dc.subjecttesticular damageen_US
dc.titleQuercetin prevents docetaxel- induced testicular damage in ratsen_US
dc.typeArticleen_US

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