The effect of tramadole hcl and paracetamol on fracture healing in rat tibia model

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dc.contributor.authorAyranci, Baris
dc.contributor.authorKalender, Ali Murat
dc.contributor.authorSevimli, Reşit
dc.contributor.authorKorkmaz, Mehmet Fatih
dc.contributor.authorBilal, Ökkeş
dc.date.accessioned2024-08-04T19:53:22Z
dc.date.available2024-08-04T19:53:22Z
dc.date.issued2017
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn our research, we aim to study the effects of combined usage of tramadole HCl + paracetamol on rat tibia fracture model. In our study, 60 Wistar-Albino type male rats, weighted at 300-350 g., were divided as “control” and “test” ( tramadole HCl + paracetamol) groups Under general anesthesia, standard closed fractures were created on right tibias of all rats using blunt ended needle holder with three point principle and then closed reduction and fixing with intramedullary nail (0.7 mm) were provided. After fracture treatment of 30 rats in the test group, starting at the same day, 40mg/kg/day tramadole HCL was introduced as daily intermuscular dosage until they were sacrificed. Rats were sacrificed after the fractures as groups of 10 individuals at 2nd, 4th and 6th weeks. Healing fractured tibias were examined mechanically, radiologically, histopathologically. Results: No positive or negative radiological, biochemical and histological effect was detected after the long duration of tramadole HCL + paracetamol usage, starting from the first day and reaching to 6 weeks, in healing process of closed tibia fractures created and fixed with IM nails in rats. Considering the negative effects of NSAIDs on fracture healing, we think that tramadole HCl + paracetamol combination is a safe option in postoperative pain treatment after fractureen_US
dc.identifier.endpage85en_US
dc.identifier.issn2147-0634
dc.identifier.issue1en_US
dc.identifier.startpage81en_US
dc.identifier.trdizinid263771en_US
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/263771
dc.identifier.urihttps://hdl.handle.net/11616/89728
dc.identifier.volume6en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofMedicine Scienceen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleThe effect of tramadole hcl and paracetamol on fracture healing in rat tibia modelen_US
dc.typeArticleen_US

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